Related Experiment Video
Updated: Sep 8, 2025

Gastrointestinal Motility Monitor GIMM
Published on: December 1, 2010
Grape seed powder increases gastrointestinal motility
Na Ri Choi1, Jeong Nam Kim1, Min Ji Kwon1
1Division of Longevity and Biofunctional Medicine, Pusan National University School of Korean Medicine, Yangsan 50612, Republic of Korea.
Abstract:
Grape seed is an important natural bioactive product with various health benefits. Interstitial cells of Cajal (ICCs) are pacemaker cells in the gastrointestinal (GI) tract. The present study investigated the effects of grape seed powder (GSP) on ICC properties and GI motility. GSP depolarized the pacemaker potentials of ICCs in a dose‑dependent manner. Y25130 or SB269970 slightly inhibited GSP‑induced effects. However, Y25130 and SB269970 together completely blocked GSP-induced effects. In the presence of inhibitors of protein kinase C, protein kinase A, or mitogen-activated protein kinase, GSP‑induced ICC depolarization was inhibited. GSP increased the intestinal transit rate in normal mice and in mice with acetic acid-induced GI motility disorder. In addition, the levels of motilin and substance P were elevated after GSP dosing. These results demonstrate that GSP can regulate GI motility, and therefore, it is a potential therapeutic agent for treating GI motility disorders.
Related Concept Videos
Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists
Gastric Motility
Peristaltic Waves and Chyme Formation
Upon food entry, the stomach initiates...
Drugs Affecting GI Tract Motility: Dopamine Receptor Antagonists
Gastrointestinal Motility Disorders
Drugs Affecting GI Tract Motility: Bulk-Forming and Stimulant Laxatives
Bulk-forming laxatives, such as psyllium, methylcellulose, and polycarbophil, absorb water in the intestine, increasing stool bulk and promoting bowel movement. This...
Drugs Affecting GI Tract Motility: Adsorbents as Antidiarrheal Agents
Adsorbents...

