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Grape seed powder increases gastrointestinal motility.

Na Ri Choi1, Jeong Nam Kim1, Min Ji Kwon1

  • 1Division of Longevity and Biofunctional Medicine, Pusan National University School of Korean Medicine, Yangsan 50612, Republic of Korea.

International Journal of Medical Sciences
|June 13, 2022
PubMed
Summary

Grape seed powder (GSP) positively impacts gastrointestinal (GI) motility by affecting pacemaker cells. This natural product shows potential for treating GI motility disorders.

Keywords:
Bioactive productGastrointestinal motilityGrape seedICCInterstitial cell of Cajal

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Area of Science:

  • Gastroenterology
  • Pharmacology
  • Natural Products Research

Background:

  • Grape seed is recognized for its bioactive compounds and health benefits.
  • Interstitial cells of Cajal (ICCs) are crucial pacemaker cells regulating gastrointestinal (GI) motility.
  • Understanding GSP's effects on ICCs and GI function is important for therapeutic applications.

Purpose of the Study:

  • To investigate the effects of grape seed powder (GSP) on ICC properties and GI motility.
  • To elucidate the mechanisms underlying GSP's influence on ICCs and GI function.

Main Methods:

  • Dose-dependent analysis of GSP's effect on ICC pacemaker potentials in vitro.
  • Assessment of GSP's impact on GI transit rate in normal and disorder models.
  • Investigation of signaling pathways (PKC, PKA, MAPK) and neurotransmitter levels (motilin, substance P) following GSP administration.

Main Results:

  • GSP dose-dependently depolarized ICC pacemaker potentials, an effect blocked by combined Y25130 and SB269970.
  • GSP-induced ICC depolarization was inhibited by blocking protein kinase C, A, or MAPK pathways.
  • GSP enhanced intestinal transit rate in vivo and increased motilin and substance P levels.

Conclusions:

  • GSP modulates GI motility by influencing ICC pacemaker activity through kinase signaling pathways.
  • GSP demonstrates potential as a therapeutic agent for managing GI motility disorders.