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Cercosporin-Photocatalyzed [4+1]- and [4+2]-Annulations of Azoalkenes Under Mild Conditions
Published on: July 17, 2020
Pyrone and isocoumarin derivatives from the endophytic fungus Cytospora rhizophorae
Hongxin Liu1, Yanjiang Zhang2,3, Yuchan Chen1
1State Key Laboratory of Applied Microbiology Southern China, Guangdong Open Laboratory of Applied Microbiology, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, China. wmzhang@gdim.cn.
Abstract:
Cytospone A (1), a pyrone and isocoumarin hetero-dimer possessing an unprecedented skeleton with a polyoxygen-hetero 6/6/6/6 tetracyclic fused ring system, and three other biosynthetic precursors cytospones B-D (2-4), along with eleven known compounds were purified from Cytospora rhizophorae A761. The deduced structure of cytospone A represents the first family of natural hetero-dimers comprising pyrone and isocoumarin moieties. A plausible biogenetic pathway involving an intriguing Knoevenagel condensation/6π electrocyclization cascade sequence as the key chemical transformation is proposed.
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