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Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
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Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

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The genetic risk factors for pregnancy-induced hypertension: Evidence from genetic polymorphisms

Wenwen Wei1, Xin Wang1, Yuanzhong Zhou2

  • 1School of Basic Medical Sciences, Special Key Laboratory of Ocular Diseases of Guizhou Province, Zunyi Medical University, Zunyi, China.

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
|June 13, 2022
PubMed

Insights

Pregnancy-induced hypertension (PIH) is a severe complication affecting maternal health globally. This review explores genetic factors in systems like renin-angiotensin and inflammation to understand PIH causes.

Area of Science:

  • Obstetrics and Gynecology
  • Medical Genetics
  • Cardiovascular Physiology

Background:

  • Pregnancy-induced hypertension (PIH) encompasses conditions like preeclampsia and gestational hypertension.
  • PIH contributes significantly to global maternal mortality, accounting for about 9% of all maternal deaths.
  • Genetic factors are increasingly recognized as crucial in the development of PIH.

Purpose of the Study:

  • To review and summarize genetic risk factors implicated in PIH.
  • To identify potential genetic contributors across various physiological systems.
  • To offer new insights into the pathogenesis of PIH.

Main Methods:

  • This study is a narrative review of existing literature.
  • It synthesizes findings from case-control studies on genetic factors in PIH.
  • The review focuses on specific biological systems and pathways.

Main Results:

  • Genetic factors in the renin-angiotensin system are associated with PIH.
  • Dysregulation of the endothelin system may contribute to PIH.
  • Inflammatory factors and oxidative stress pathways are also linked to PIH development.
  • Other functional networks involving genetic variations are discussed.

Conclusions:

  • Genetic predisposition plays a significant role in the multifactorial nature of PIH.
  • Understanding these genetic factors is key to unraveling PIH pathogenesis.
  • Further research into genetic risk factors may inform prevention and treatment strategies.

Keywords:
geneticspreeclampsiapregnancy-induced hypertensionsingle nucleotide polymorphismssusceptibility

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