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Genetic programming of development: a model.

D W Bailey

    Differentiation; Research in Biological Diversity
    |January 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    A novel model proposes gene subsets control multicellular organism development through sequential epigenetic activation. This cascade mechanism explains pattern formation, morphogenesis, and regeneration, offering testable molecular predictions.

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    Area of Science:

    • Developmental biology
    • Molecular genetics
    • Systems biology

    Background:

    • Multicellular development relies on intricate genetic programming.
    • A significant portion of genes is dedicated to orchestrating developmental processes.

    Purpose of the Study:

    • To propose a model for genetic control of multicellular development.
    • To explain how gene activity changes during ontogenesis.
    • To provide a framework for understanding pattern formation, morphogenesis, and regeneration.

    Main Methods:

    • Conceptual modeling of gene regulatory networks.
    • Proposing compartmentalization of genes into activity-based subsets.
    • Describing a mechanism for automatic, sequential subset activation via gene products.

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  • Modeling a cascading activation system analogous to dominoes.

    • Main Results:

    • A model where gene subsets transiently control cell epigenetic activities.
    • A unidirectional, hierarchical activation cascade through developmental stages.
    • The model explains key developmental phenomena like pattern formation and regeneration.

    Conclusions:

    • The proposed genetic programming model offers a mechanistic explanation for complex developmental processes.
    • This model predicts specific molecular events and testable hypotheses.
    • It provides a unified framework for understanding pattern formation, morphogenesis, and regeneration.