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Updated: Sep 8, 2025
05:39
A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis
Published on: November 30, 2021
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Neurologic Consequences of Neonatal Necrotizing Enterocolitis
Jonathan A Berken1, Jill Chang2,3
1Department of Pediatrics, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA.
Developmental Neuroscience
|June 13, 2022
Summary
Necrotizing enterocolitis (NEC), a severe infant disease, is linked to long-term brain injury and neurodevelopmental delay. Understanding NEC
Area of Science:
- Neonatal Medicine
- Pediatric Gastroenterology
- Neuroscience
Background:
- Necrotizing enterocolitis (NEC) is a critical gastrointestinal condition in premature infants, associated with significant mortality and long-term morbidities.
- Survivors of NEC often exhibit neurodevelopmental delays, exceeding those attributed solely to prematurity.
- The precise mechanisms linking NEC to brain injury are not fully understood, hindering effective interventions.
Purpose of the Study:
- To review current clinical and experimental research on brain injury associated with NEC.
- To elucidate the epidemiology and long-term neurodevelopmental outcomes in NEC survivors.
- To explore the proposed pathogenesis of brain injury in the context of NEC.
Main Methods:
- Systematic review of clinical studies on NEC.
- Analysis of experimental research investigating NEC-associated neurological impairments.
- Synthesis of data on NEC epidemiology and neurodevelopmental outcomes.
Main Results:
- NEC presents a substantial risk for neurological impairment in premature infants.
- Hypoxia-ischemia, nutritional factors, infection, and gut inflammation are implicated in NEC-related brain injury.
- The developing brain is vulnerable to the systemic effects of NEC.
Conclusions:
- NEC-associated brain injury is a significant concern with multifactorial origins.
- Further research into the pathways connecting gut inflammation and brain development is crucial.
- Developing targeted preventative and protective strategies for NEC-induced neurological damage is a priority.
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