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Assessing systemic vascular resistance using arteriolar pulse transit time based on multi-wavelength
Yiqian Lu1,2, Zengjie Yu1,2, Jikui Liu1
1Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, People's Republic of China.
Physiological Measurement
|June 13, 2022
Summary
This study introduces a novel method using arteriolar pulse transmit time (aPTT) to continuously measure systemic vascular resistance (SVR). The technique, validated through cold and emotional stimuli, offers a new way to track blood pressure regulation.
Area of Science:
- Physiology
- Biomedical Engineering
- Cardiovascular Research
Background:
- Systemic vascular resistance (SVR) is crucial for blood pressure regulation, influenced by sympathetic nerve activity.
- Continuous measurement of SVR is currently lacking, hindering real-time monitoring and research.
- Arteriolar function directly impacts SVR, making its assessment vital.
Purpose of the Study:
- To develop and validate a method for continuously tracking changes in SVR.
- To utilize arteriolar pulse transmit time (aPTT) as a surrogate marker for SVR.
- To assess the correlation between aPTT, sympathetic nerve activity, and SVR.
Main Methods:
- Simultaneous collection of multi-wavelength photoplethysmogram (PPG), electrocardiogram (ECG), and galvanic skin response (GSR) data.
- Development of a Least Mean Square (LMS)-based algorithm to calculate aPTT from PPG signals.
- Experimental validation using cold and emotional stimulation, with laser Doppler for blood perfusion monitoring and dynamic time warping (DTW) for correlation analysis.
Main Results:
- The LMS-based method successfully extracted changes in aPTT.
- aPTT showed an inverse relationship with blood perfusion during recovery from cold stimulation (aPTT decreased as perfusion increased).
- aPTT demonstrated a stronger correlation with GSR during emotional stimulation compared to traditional pulse transit time (PTT) in 70% of participants.
Conclusions:
- The developed method provides a continuous and measurable parameter, aPTT, that closely reflects changes in SVR.
- Experimental validation confirms the utility of aPTT in tracking SVR dynamics.
- This non-invasive approach holds promise for improved monitoring of cardiovascular regulation.
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