Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

190
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
190
Optimizing Chromatographic Separations01:15

Optimizing Chromatographic Separations

485
Optimizing chromatographic separations is crucial for obtaining clean separations in a minimum amount of time. Optimization is required for several factors, including kinetic effects related to band broadening, plate height, capacity factor, and separation factor.
Band broadening refers to spreading solute bands as they travel through the column. This broadening can impact resolution. Plate height (H) represents the length required for one theoretical plate. A lower plate height corresponds to...
485
Factors Influencing Drug Absorption: Physicochemical Parameters01:22

Factors Influencing Drug Absorption: Physicochemical Parameters

425
The physicochemical characteristics of drugs play a crucial role in formulating stable and bioavailable drug products. The solubility of a drug, governed by the varying pH along the GI tract and its dissociation constant (pKa), is pivotal in determining its ionization state and absorption rate. Notably, weak acids and bases remain unionized and are absorbed more rapidly.
Enhanced drug absorption can be achieved by reducing particle sizes and increasing surface areas, thereby facilitating...
425
Ion-Exchange Chromatography01:09

Ion-Exchange Chromatography

756
Ion-exchange chromatography, or IEC, is a technique for separating ions based on their affinity for the stationary phase. The stationary phase is a cross-linked polymer resin with covalently attached ionic functional groups. The functional groups can be either positively charged (cation exchangers) or negatively charged (anion exchangers). A cation exchanger consists of a polymeric anion and active cations, while an anion exchanger is a polymeric cation with active anions. The choice of...
756
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

258
Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
258
Ion Exchange01:17

Ion Exchange

656
Ion exchange chromatography separates charged molecules from a solution by reversibly exchanging them with mobile, or 'active', ions associated with the oppositely charged stationary phase. This method can be used to separate ions, soften and deionize water, and purify solutions. The polymers comprising the ion-exchange column are high-molecular-weight and chemically stable polymers, crosslinked to be porous and essentially insoluble. They are also functionalized with either acidic or...
656

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nano-Based Therapeutics in Rare Disease Management: Current Perspectives, Challenges, and Unmet Needs.

Current neuropharmacology·2026
Same author

Advancing Regenerative Medicine with 3D Bioprinting: Techniques, Biomaterials, and Clinical Applications.

Current medicinal chemistry·2026
Same author

Platelet-derived extracellular vesicles as neurodegenerative disease biomarkers.

Clinica chimica acta; international journal of clinical chemistry·2026
Same author

Exosomal miRNA in cerebrospinal fluid as biomarkers for neurodegenerative disease.

Clinica chimica acta; international journal of clinical chemistry·2026
Same author

Cuproptosis-related circulating non-coding RNAs as diagnostic and prognostic biomarkers in oncology.

Clinica chimica acta; international journal of clinical chemistry·2026
Same author

Transforming cisplatin therapy: a localized, injectable poly(anhydride-ester) depot for safer and more effective head and neck cancer treatment.

Investigational new drugs·2026

Related Experiment Video

Updated: Sep 8, 2025

Author Spotlight: Advancing Antimicrobial Resistance Research with Innovative Approaches and Synthetic Compounds
05:59

Author Spotlight: Advancing Antimicrobial Resistance Research with Innovative Approaches and Synthetic Compounds

Published on: September 27, 2024

2.2K

Active pharmaceutical ingredients (APIs) in ionic liquids: An effective approach for API physiochemical parameter

Mayank Handa1, Waleed H Almalki2, Rahul Shukla1

  • 1Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research-Raebareli, Lucknow, UP, India.

Drug Discovery Today
|June 13, 2022
PubMed
Summary

Active pharmaceutical ingredients (APIs) converted into ionic liquids (ILs) offer enhanced drug delivery. This approach improves solubility, stability, and release, showing great potential in pharmaceutical formulations.

Keywords:
Cell cytotoxicityDissolutionsIonic liquidsPermeation enhancerPolymorphismSolubilityThermal stabilityUptake

More Related Videos

Pretreatment of Lignocellulosic Biomass with Low-cost Ionic Liquids
10:42

Pretreatment of Lignocellulosic Biomass with Low-cost Ionic Liquids

Published on: August 10, 2016

18.2K
Synthesis of Ionic Liquid Based Electrolytes, Assembly of Li-ion Batteries, and Measurements of Performance at High Temperature
11:04

Synthesis of Ionic Liquid Based Electrolytes, Assembly of Li-ion Batteries, and Measurements of Performance at High Temperature

Published on: December 20, 2016

13.1K

Related Experiment Videos

Last Updated: Sep 8, 2025

Author Spotlight: Advancing Antimicrobial Resistance Research with Innovative Approaches and Synthetic Compounds
05:59

Author Spotlight: Advancing Antimicrobial Resistance Research with Innovative Approaches and Synthetic Compounds

Published on: September 27, 2024

2.2K
Pretreatment of Lignocellulosic Biomass with Low-cost Ionic Liquids
10:42

Pretreatment of Lignocellulosic Biomass with Low-cost Ionic Liquids

Published on: August 10, 2016

18.2K
Synthesis of Ionic Liquid Based Electrolytes, Assembly of Li-ion Batteries, and Measurements of Performance at High Temperature
11:04

Synthesis of Ionic Liquid Based Electrolytes, Assembly of Li-ion Batteries, and Measurements of Performance at High Temperature

Published on: December 20, 2016

13.1K

Area of Science:

  • Biomedical Sciences
  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Ionic liquids (ILs) are versatile solvents and enhancers in biomedical and pharmaceutical applications.
  • Active pharmaceutical ingredients (APIs) can be synthesized into ILs, offering unique properties for drug delivery systems.

Purpose of the Study:

  • To review the utilization and physiochemical characteristics of APIs in ionic liquid form.
  • To explore the benefits of using API-ILs in preformulation and formulation development for enhanced drug delivery.

Main Methods:

  • Literature review of studies involving APIs synthesized as ionic liquids.
  • Analysis of physiochemical properties and drug delivery performance of API-ILs.
  • Exploration of formulation strategies incorporating API-ILs, such as solutions, emulsions, and nanoparticles.

Main Results:

  • API-ILs demonstrate tunable solubility, enhanced thermal stability, and improved dissolution rates.
  • Controlled drug release, increased permeability, and modulated cytotoxicity against tumor cells are observed.
  • API-ILs serve as active components in various drug delivery systems, including nanoparticles.

Conclusions:

  • Converting APIs into ionic liquids is a promising strategy for advanced drug delivery.
  • This approach significantly enhances API physicochemical properties, benefiting formulation development.
  • API-ILs represent a novel platform for creating effective and tailored drug delivery solutions.