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Myeloid cell-targeted therapies for solid tumours.

Sangeeta Goswami^1,2, Swetha Anandhan^1,3, Deblina Raychaudhuri²

¹Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Nature Reviews. Immunology

|June 13, 2022

Summary

This summary is machine-generated.

Myeloid cells in the tumor microenvironment play complex roles in cancer progression and therapy resistance. Understanding and targeting these cells offers new strategies to improve cancer treatment outcomes.

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Area of Science:

Oncology
Immunology
Cell Biology

Background:

Myeloid cells are abundant in the tumor microenvironment, exhibiting diverse, plastic phenotypes.
These cells can promote or suppress anti-tumor immunity and influence resistance to cancer therapies, including immunotherapy.

Purpose of the Study:

To review key features of monocyte and macrophage biology relevant to cancer therapy targets.
To identify areas needing further research for developing rational combination strategies to enhance patient outcomes.
To discuss current and emerging therapeutic approaches modulating myeloid cell functions.

Main Methods:

Review of current literature on myeloid cell biology in cancer.
Analysis of therapeutic strategies targeting myeloid cell recruitment, survival, and activity.
Discussion of novel approaches like genetically engineered myeloid cells.

Main Results:

Myeloid cell subsets (monocytes, macrophages, etc.) have complex roles in tumor progression and therapy resistance.
Therapeutic strategies focus on modulating myeloid cell functions via receptors, signaling, epigenetics, and metabolism.
Advances include genetically engineered myeloid cells for therapeutic applications.

Conclusions:

Targeting myeloid cell biology is crucial for improving cancer therapy efficacy.
Further understanding of myeloid cell plasticity and tumor interactions is needed for optimal combinatorial strategies.
Modulating myeloid cell activity presents promising avenues for novel cancer treatments.