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Updated: Sep 8, 2025
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Visualization of SARS-CoV-2 using Immuno RNA-Fluorescence In Situ Hybridization
Published on: December 23, 2020
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Differing coronavirus genres alter shared host signaling pathways upon viral infection
Diana Cruz-Pulido1,2, Wilberforce Zachary Ouma3, Scott P Kenney4,5
1Department of Veterinary Preventive Medicine, The Ohio State University, Columbus, OH, 43210, USA.
Scientific Reports
|June 13, 2022
Summary
Distant coronaviruses share common immune pathways and genes, offering new therapeutic targets. Identifying these shared differentially expressed genes (DEGs) across viruses like SARS-CoV-2 provides a strategy against future coronavirus pandemics.
Area of Science:
- Virology
- Immunology
- Genomics
Background:
- Coronaviruses are significant viral pathogens with pandemic potential, necessitating in-depth study and new therapeutic targets.
- Cross-species transmission of coronaviruses, exemplified by COVID-19, highlights the need for understanding interspecies viral interactions.
Purpose of the Study:
- To investigate shared host immune-associated pathways and genes among distant coronavirus genres.
- To identify common differentially expressed genes (DEGs) across different coronavirus infections as potential therapeutic targets.
Main Methods:
- Comparative transcriptome analysis of epithelial cell lines infected with swine acute diarrhea syndrome, SARS-CoV-2, and porcine deltacoronavirus (PDCoV).
- Identification and analysis of differentially expressed genes (DEGs) within common immune-associated pathways.
Main Results:
- Distant coronaviruses (Alpha-, Beta-, and Deltacoronaviruses) share common host immune-associated pathways and genes.
- Twenty-three pathways and 21 DEGs across 10 immune response pathways were shared among the studied viruses.
- A positive correlation was observed between PDCoV and SARS-CoV-2 infections, though distinct replication strategies may be employed.
Conclusions:
- Shared DEGs across distant coronaviruses represent promising targets for broad-spectrum antiviral therapeutics.
- This comparative host transcriptome analysis provides novel insights into coronavirus-host interactions and potential pandemic preparedness strategies.
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