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Posttranslational modifications in diabetes: Mechanisms and functions

Ang Hu1, Haohong Zou1, Bin Chen1,2

  • 1Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Gannan Medical University, 323 National Road, Ganzhou, 341000, Jiangxi, China.

Reviews in Endocrine & Metabolic Disorders
|June 13, 2022
PubMed

Insights

Posttranslational modifications (PTMs) are key to understanding diabetes complexity. This review explores PTMs

Area of Science:

  • Biochemistry
  • Endocrinology
  • Molecular Biology

Background:

  • Diabetes mellitus is a global chronic disease with significant morbidity and mortality.
  • Diabetes involves complex cellular signaling pathways influenced by posttranslational modifications (PTMs).

Purpose of the Study:

  • To provide a comprehensive overview of the interplay between PTMs and diabetes (Types 1 and 2).
  • To discuss the therapeutic potential of PTMs in managing diabetes.
  • To suggest future research directions for understanding metabolic diseases.

Main Methods:

  • Literature review and synthesis of existing research on PTMs and diabetes.

Main Results:

  • PTMs play a critical role in the regulatory networks underlying diabetes.
  • Understanding PTM mechanisms is crucial for diabetes prediction, diagnosis, and treatment.

Conclusions:

  • PTMs are integral to diabetes pathogenesis and progression.
  • Targeting PTMs offers promising avenues for novel diabetes therapies.
  • Further research into PTMs will advance our understanding of metabolic diseases.
Keywords:
AutoimmunePosttranslational modificationsType 1 diabetesType 2 diabetes

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