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Efficient capture and stabilization of iodine via gas-solid reaction using cyclodextrin metal-organic frameworks
Jiacai Chen1, Tao Guo2, Xiaohong Ren3
1School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing 210046, China; Center for Drug Delivery Systems, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201210, China.
Carbohydrate Polymers
|June 14, 2022
Summary
Researchers developed a novel potassium iodide cyclodextrin metal-organic framework (KI-CD-MOF) to stabilize iodine for wound infection treatment. This new material significantly enhances iodine
Area of Science:
- Materials Science
- Nanotechnology
- Medicinal Chemistry
Background:
- Iodine is a crucial antiseptic agent but suffers from poor solubility and stability.
- Developing stable and effective iodine delivery systems is essential for wound care applications.
Purpose of the Study:
- To synthesize and characterize a novel metal-organic framework (MOF) for enhanced iodine stabilization and delivery.
- To investigate the inclusion mechanism and properties of iodine within the KI-CD-MOF structure.
- To evaluate the improved solubility, stability, and antibacterial activity of iodine delivered via KI-CD-MOF.
Main Methods:
- Gas-solid reaction for iodine loading into potassium iodide cyclodextrin metal-organic frameworks (KI-CD-MOF).
- X-ray photoelectron spectroscopy and potentiometric titration to confirm triiodide formation (I3-).
- Molecular simulation, synchrotron radiation Fourier transform infrared spectroscopy, differential scanning calorimetry, powder X-ray diffraction, and N2 adsorption to elucidate the iodine inclusion mechanism.
- Solubility, stability, and antibacterial activity tests.
Main Results:
- Successfully prepared KI-CD-MOF capable of stabilizing iodine (I2) as I3- within its porous structure.
- Demonstrated a 3.86-fold enhancement in the apparent solubility of iodine in water.
- Confirmed that uniformly distributed iodide ions within the MOF are critical for improved solubility, stability, and bacteriostatic effects.
- Characterized the iodine inclusion mechanism using various spectroscopic and simulation techniques.
Conclusions:
- KI-CD-MOF is an effective platform for capturing and stabilizing iodine, significantly improving its physicochemical properties.
- The enhanced solubility, stability, and antibacterial efficacy of iodine delivered by KI-CD-MOF show great potential for wound infection treatment.
- This MOF-based approach offers a promising strategy for developing advanced iodine-based antimicrobial agents.
