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Published on: December 13, 2024
Citric acid crosslinked sphingan WL gum hydrogel films supported ciprofloxacin for potential wound dressing
Aiping Chang1, Zeli Ye1, Zhenquan Ye1
1Engineering Research Center of Industrial Biocatalysis, Fujian-Taiwan Science and Technology Cooperation Base of Biomedical Materials and Tissue Engineering, Fujian Provincial Key Laboratory of Advanced Materials Oriented Chemical Engineering, Fujian Provincial Key Laboratory of Polymer Materials, College of Chemistry and Materials Science, Fujian Normal University, 32 Shangsan Road, Fuzhou 350007, People's Republic of China.
Abstract:
Sphingan WL gum (WL), a kind of exopolysaccharides, is produced by Sphingomonas sp. WG. In this study, citric acid (CA) crosslinked WL hydrogel films were firstly developed for potential wound dressing application. ATR-FTIR and TG results suggested the occurrence of esterification crosslinking. SEM analysis showed that this aided covalent crosslinking could prevent their porous structures from collapsing when swelling. Due to the deprotonation of carboxyl groups, the water absorption capacity of WL-CA hydrogel films increased with the increase of pH (maximum swelling ratio = 38 g/g). The covalent crosslinked swollen WL-CA hydrogels exhibited certain hydrolytic stability, high porosity (>60%), moderate tissue adhesion, and good rheological property (G' > G″, G' up to 2 kPa). WL-CA-CIP hydrogel films loaded with antibiotic ciprofloxacin (CIP) showed sustained drug release properties, long-lasting antibacterial activity, and superior biocompatibility. All the results indicated that WL-based hydrogels were potential candidates for wound dressing applications.
