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Polysaccharides-based delivery system for efficient encapsulation and controlled release of food-derived active
Chengtao Han1, Li Fang1, Shixin Song1
1College of Food Science and Engineering, Jilin Agricultural University, Changchun 130118, PR China.
Carbohydrate Polymers
|June 14, 2022
Summary
A novel polysaccharide delivery system effectively encapsulates peanut peptides (PP), protecting them from degradation and enhancing intestinal absorption. This biocompatible system shows significant potential for oral peptide delivery.
Area of Science:
- Biomaterials Science
- Drug Delivery Systems
- Food Science and Technology
Background:
- Peanut peptides (PP) possess valuable bioactivities but are susceptible to degradation in the gastrointestinal tract.
- Developing effective delivery systems is crucial for enhancing the stability and bioavailability of therapeutic peptides.
Purpose of the Study:
- To design and fabricate a polysaccharides-based delivery system for peanut peptides (PP).
- To evaluate the encapsulation efficiency, stability, controlled release, antioxidant activity, and intestinal absorption of PP using the developed system.
Main Methods:
- Fabrication of a polyelectrolyte complex (TMC-PP-SA) via electrostatic self-assembly of N-trimethyl chitosan (TMC) and sodium alginate (SA).
- Characterization of the complex's morphology, stability, and encapsulation efficiency.
- In vitro release studies under simulated gastric and intestinal conditions.
- Assessment of antioxidant activity and ex vivo intestinal permeation.
- In vitro cytotoxicity evaluation.
Main Results:
- The TMC-PP-SA complex demonstrated uniform spherical morphology, good stability, and high encapsulation efficiency for PP.
- The system successfully inhibited PP release in simulated gastric conditions and enhanced release in simulated intestinal conditions.
- Encapsulated PP exhibited significantly improved antioxidant activity compared to free PP.
- Ex vivo studies showed approximately 41.76% PP absorption in the intestine.
- Cytotoxicity assays confirmed the biocompatibility and safety of the TMC-PP-SA complex.
Conclusions:
- The developed polysaccharides-based delivery system effectively protects peanut peptides from degradation.
- The system facilitates enhanced intestinal absorption and preserves the bioactivity of encapsulated peptides.
- This delivery system holds significant promise for improving the oral administration of active peptides.
