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A Case Report of Hyperostosis Frontalis Interna.

Luis A Alvarez¹, William Corrigan¹, Seth Gardner¹

¹College of Osteopathic Medicine, Lake Erie College of Osteopathic Medicine Bradenton, Bradenton, USA.

|June 14, 2022

Summary

A rare and severe case of hyperostosis frontalis interna (HFI), a condition of abnormal bone growth in the skull, was found in an 89-year-old female cadaver. This unique HFI manifestation may aid clinicians in patient evaluation.

Keywords:

bone growth class c hfi estrogen hfi hyperostosis frontalis interna postmenopause

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Area of Science:

Neuropathology
Skeletal Biology
Gross Anatomy

Background:

Hyperostosis frontalis interna (HFI) is a condition characterized by bone thickening on the inner surface of the frontal bone.
While often asymptomatic, severe forms and atypical presentations warrant further investigation.
Understanding the spectrum of HFI is crucial for accurate clinical assessment.

Observation:

A routine cadaveric dissection revealed an unusual case of hyperostosis frontalis interna (HFI).
The specimen exhibited multiple layers of spongy bone growth and asymmetrical nodular formations.
Atypical superior sagittal sinus involvement was also noted, classifying this as a rare, severe form (Class C).

Findings:

The observed HFI presented with extensive, layered bone deposition and irregular growths.
The involvement of the superior sagittal sinus is an uncommon feature for this condition.
This case represents a severe manifestation (Class C) of hyperostosis frontalis interna.

Implications:

This unique HFI case highlights the variability in its presentation and severity.
Further documentation of rare HFI forms can refine diagnostic criteria and clinical risk assessment.
Such findings contribute to the understanding of HFI's pathological spectrum and potential clinical significance.