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miRNAs and the Hippo pathway in cancer: Exploring the therapeutic potential (Review)

Taruna Arora1, Mohd Adnan Kausar2, Shimaa Mohammed Aboelnaga3

  • 1Division of Reproductive Biology, Maternal & Child Health, Department of Health Research, ICMR, MOHFW, Government of India, Ansari Nagar, New Delhi 110029, India.

Oncology Reports
|June 14, 2022
PubMed

Insights

The hippo signaling pathway and microRNAs (miRNAs) are crucial in cancer development. Understanding their complex interplay offers new avenues for effective cancer therapeutics and overcoming drug resistance.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Cancer is a leading global cause of death, often linked to cellular dysregulation.
  • The hippo signaling pathway controls organ size by regulating cell proliferation and apoptosis.
  • MicroRNAs (miRNAs), non-coding RNAs, are implicated in various cancers and regulate gene expression.

Purpose of the Study:

  • To elucidate the intricate mechanisms of the hippo signaling pathway and miRNA biogenesis.
  • To explore the cross-regulatory links between miRNAs and the hippo pathway in cancer.
  • To review miRNA-based therapeutics and the challenge of anticancer drug resistance.

Main Methods:

  • Literature review focusing on molecular mechanisms.
  • Analysis of the interplay between hippo pathway components and miRNA regulation.
  • Synthesis of current research on miRNA therapeutics and drug resistance.

Main Results:

  • Dysregulation of the hippo pathway can lead to cancer-like conditions.
  • miRNAs and the hippo pathway exhibit complex cross-regulatory interactions.
  • Altered miRNA expression is a hallmark of various cancer types.

Conclusions:

  • Understanding the hippo pathway-miRNA axis is vital for cancer biology.
  • Targeting miRNAs presents a promising therapeutic strategy for cancer treatment.
  • Addressing drug resistance mechanisms is essential for improving patient outcomes.
Keywords:
Hippo pathwayTAZYAPdrug‑resistantmicroRNAstumorigenesis

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