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Related Experiment Videos

Terrien's marginal degeneration: clinicopathologic case reports.

D R Guyer, J Barraquer, P J McDonnell

    Graefe'S Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie
    |January 1, 1987
    PubMed
    Summary

    Terrien's marginal degeneration involves stromal thinning and vascularization. Breaks in Descemet's membrane contribute to these changes, distinguishing it from pellucid degeneration.

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    Area of Science:

    • Ophthalmology
    • Corneal Pathology

    Background:

    • Terrien's marginal degeneration is a rare, progressive thinning of the peripheral cornea.
    • Its clinical and histopathologic features share similarities with pellucid marginal degeneration.

    Observation:

    • Seven cases of Terrien's marginal degeneration were analyzed, including lamellar and full-thickness corneal specimens.
    • Histopathology revealed stromal thinning, vascularization, lipid keratopathy, and absence of Bowman's membrane in all cases.
    • Descemet's membrane was thickened, and endothelium was intact, with evidence of healed ruptures in three full-thickness specimens.

    Findings:

    • Healed ruptures of Descemet's membrane were observed, with one specimen showing multiple successive ruptures.
    • The corneal endothelium in affected areas produced a significantly thickened basement membrane (up to 35 microns).

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  • Distinguishing features include vascularization, scarring, and lipid keratopathy in Terrien's, versus clear thinning in pellucid degeneration.

    • Implications:

    • Breaks in Descemet's membrane are implicated as a contributing factor to the observed histopathologic changes in Terrien's marginal degeneration.
    • Understanding these features aids in differentiating Terrien's from pellucid degeneration.
    • Further research into the pathogenesis of Descemet's membrane rupture in peripheral corneal thinning is warranted.