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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
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Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
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Merkel Cell Polyomavirus Infection and Detection
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Merkel cell carcinoma.

Morten Kristoffer Nyrud1, Åse Bratland2, Linn Landrø3

  • 1Seksjon for onkologisk plastikkirurgi, Avdeling for plastikk- og rekonstruktiv kirurgi, Oslo universitetssykehus, Radiumhospitalet, * Nåværende arbeidssted:, Seksjon for plastikk- og rekonstruktiv kirurgi, Kirurgisk avdeling, Sykehuset Østfold Moss.

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|June 14, 2022
PubMed
Summary
This summary is machine-generated.

Merkel cell carcinoma is a rare, aggressive skin cancer with high metastatic potential. Early detection and prompt treatment, including surgical excision and sentinel-node biopsy, are crucial for managing this condition.

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Area of Science:

  • Oncology
  • Dermatology
  • Pathology

Background:

  • Merkel cell carcinoma (MCC) is an uncommon but aggressive neuroendocrine skin cancer.
  • MCC exhibits a high potential for metastasis, particularly in older individuals with sun-exposed skin lesions.

Purpose of the Study:

  • To outline the diagnostic and management strategies for Merkel cell carcinoma.
  • To emphasize the importance of early recognition and specialized care for MCC patients.

Main Methods:

  • Diagnosis involves integrating patient history, clinical presentation, radiological imaging, and pathological examination.
  • Treatment recommendations include prompt surgical excision with a 1-2 cm margin and simultaneous sentinel-node biopsy.
  • Adjuvant radiation therapy may be considered for the tumor site.

Main Results:

  • Suspicion should arise from rapidly growing, non-tender cutaneous tumors on sun-exposed areas in older patients.
  • Multidisciplinary findings are essential for accurate diagnosis.
  • Timely surgical intervention and sentinel-node biopsy are critical.

Conclusions:

  • Merkel cell carcinoma requires a high index of suspicion and prompt, specialized management.
  • Integrated diagnostic approaches and timely, aggressive treatment are key to improving outcomes.
  • Care should be centralized in experienced medical facilities.