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Related Concept Videos

Symbiosis00:58

Symbiosis

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Symbiotic relationships are long-term, close interactions between individuals of different species that affect the distribution and abundance of those species. When a relationship is beneficial to both species, this is called mutualism. When the relationship is beneficial to one species but neither beneficial nor harmful to the other species, this is called commensalism. When one organism is harmed to benefit another, the relationship is known as parasitism. These types of relationships often...
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Diversity of Protists II01:27

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Alveolates are a group of organisms recognized by the presence of alveoli, which are cytoplasmic sacs located beneath the cell membrane. While their function remains uncertain, alveoli may help regulate water balance by controlling how much water enters and leaves the cell. In dinoflagellates, these structures may serve as armor plates. There are three major types of alveolates: ciliates, which move using cilia; dinoflagellates, which use flagella for movement; and apicomplexans, which are...
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Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum
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New insights on malaria.

Francesco Castelli1,2,3, Lina R. Tomasoni2

  • 1rofessor of Infectious Diseases and UNESCO Chairholder “Training and empowering human resources for health development in resource-limited countries”, University of Brescia, Italy

The New Microbiologica
|June 14, 2022
PubMed
Summary
This summary is machine-generated.

Malaria remains a significant global health threat despite control efforts. New diagnostic tools and a new vaccine offer hope, but challenges like resistance and funding persist.

Keywords:
Malariaepidemiologyimmunitytreatmentvaccine

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Area of Science:

  • * Infectious Diseases
  • * Parasitology
  • * Public Health

Background:

  • * Malaria, a deadly vector-borne disease caused by Plasmodium parasites, affects 85 countries.
  • * Despite control measures like early diagnosis, treatment, nets, and spraying, malaria persists as a major issue in endemic regions.
  • * Recent trends show stagnation in reducing morbidity and mortality due to funding, resistance, and the COVID-19 pandemic.

Purpose of the Study:

  • * To review the current status of malaria control, diagnosis, and treatment.
  • * To highlight advancements in diagnostic tools and vaccine development.
  • * To discuss challenges hindering malaria eradication efforts.

Main Methods:

  • * Review of current literature on malaria diagnosis, treatment, and control strategies.
  • * Analysis of trends in malaria morbidity and mortality.
  • * Discussion of emerging challenges, including drug and insecticide resistance.

Main Results:

  • * New, highly sensitive diagnostic tools like rapid antigenic tests and loop-mediated isothermal amplification are available.
  • * The RTS-S malaria vaccine was approved for routine use in children in 2021, despite suboptimal efficacy.
  • * Stagnating progress is attributed to limited funding, resistance, and the COVID-19 pandemic's impact.

Conclusions:

  • * Continued efforts in diagnosis, treatment, and vector control are crucial.
  • * Addressing resistance and securing sustainable funding are essential for progress.
  • * Increased population movement necessitates vigilance against imported malaria in non-endemic areas.