Regularized Asymmetric Susceptibility Tensor Imaging in the Human Brain in Vivo

Susceptibility tensor imaging (STI) is a promising tool for studying orientation-dependent tissue magnetic susceptibility and for mapping white matter fiber orientations complementary to diffusion tensor imaging (DTI). However, the limited head rotation range within modern head coils for data acquisition makes in vivo STI reconstruction ill-conditioned. Conventional STI reconstruction method is usually vulnerable to noise and requires sufficiently large head rotations to solve this ill-conditioned inverse problem. In this study, based on the recently proposed asymmetric STI (aSTI) model, a new method termed aSTI+ was proposed to improve in vivo STI reconstruction by enforcing isotropic susceptibility tensor inside cerebrospinal fluid (CSF) and applying morphology constraint in white matter. Experimental results showed superior performance of the proposed method with reduced noise, improved tissue contrast and better fiber orientation estimation over previous methods. Thus aSTI+ may promote in vivo human brain STI studies on white matter and myelin-related brain diseases.