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Viral eradication by direct-acting antivirals does not decrease the serum myostatin level in patients infected with
Kei Endo1, Takuro Sato1, Yuichi Yoshida1
1Division of Hepatology, Department of Internal Medicine, Iwate Medical University School of Medicine, Iwate, Japan.
Nutrition (Burbank, Los Angeles County, Calif.)
|June 14, 2022
Summary
Direct-acting antiviral therapy for hepatitis C virus (HCV) does not alter serum myostatin levels. This finding suggests viral eradication does not impact myostatin, a protein linked to sarcopenia in chronic liver disease patients.
Area of Science:
- Hepatology
- Virology
- Muscle Biology
Background:
- Myostatin is implicated in sarcopenia development in chronic liver disease.
- The impact of hepatitis C virus (HCV) elimination on myostatin remains unclear.
Purpose of the Study:
- To evaluate the effect of sustained virologic response (SVR24) after direct-acting antiviral (DAA) therapy on serum myostatin levels in HCV patients.
Main Methods:
- Retrospective analysis of 91 HCV patients treated with DAA between 2014-2017.
- Comparison of serum myostatin levels before and after DAA treatment (SVR24).
- Correlation analysis between myostatin and laboratory data.
Main Results:
- No significant difference in myostatin levels before and after DAA therapy (P=0.79).
- Myostatin levels were higher in men and patients with cirrhosis compared to women and chronic hepatitis patients.
- Positive correlation observed between myostatin levels and skeletal muscle index and liver fibrosis markers.
Conclusions:
- HCV viral eradication via DAA therapy does not reduce serum myostatin levels.
- Myostatin levels are associated with sex and liver disease severity in HCV patients.
Keywords:
Hepatitis C virusLiver fibrosis markerSerum myostatinSkeletal muscle indexSustained virologic responseMore Related Videos
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