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Viral eradication by direct-acting antivirals does not decrease the serum myostatin level in patients infected with

Kei Endo1, Takuro Sato1, Yuichi Yoshida1

  • 1Division of Hepatology, Department of Internal Medicine, Iwate Medical University School of Medicine, Iwate, Japan.

Nutrition (Burbank, Los Angeles County, Calif.)
|June 14, 2022
PubMed
Abstract

Insights

Direct-acting antiviral therapy for hepatitis C virus (HCV) does not alter serum myostatin levels. This finding suggests viral eradication does not impact myostatin, a protein linked to sarcopenia in chronic liver disease patients.

Area of Science:

  • Hepatology
  • Virology
  • Muscle Biology

Background:

  • Myostatin is implicated in sarcopenia development in chronic liver disease.
  • The impact of hepatitis C virus (HCV) elimination on myostatin remains unclear.

Purpose of the Study:

  • To evaluate the effect of sustained virologic response (SVR24) after direct-acting antiviral (DAA) therapy on serum myostatin levels in HCV patients.

Main Methods:

  • Retrospective analysis of 91 HCV patients treated with DAA between 2014-2017.
  • Comparison of serum myostatin levels before and after DAA treatment (SVR24).
  • Correlation analysis between myostatin and laboratory data.

Main Results:

  • No significant difference in myostatin levels before and after DAA therapy (P=0.79).
  • Myostatin levels were higher in men and patients with cirrhosis compared to women and chronic hepatitis patients.
  • Positive correlation observed between myostatin levels and skeletal muscle index and liver fibrosis markers.

Conclusions:

  • HCV viral eradication via DAA therapy does not reduce serum myostatin levels.
  • Myostatin levels are associated with sex and liver disease severity in HCV patients.
Keywords:
Hepatitis C virusLiver fibrosis markerSerum myostatinSkeletal muscle indexSustained virologic response

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