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Published on: October 16, 2013
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[Rectal leiomyosarcoma, a rare malignant tumor diagnosed in ulcerative colitis]
Benjamin Ducloux-Lebon1, Franck Brazier2, Clémence Tamarit1
1Service d'anatomie et cytologie pathologiques, CHU Amiens Nord, Place Victor-Pauchet, 80000 Amiens, France.
Annales De Pathologie
|June 14, 2022
Summary
Malignant mesenchymal tumors, such as rectal leiomyosarcomas, are exceptionally rare in patients with inflammatory bowel disease (IBD). This case highlights a leiomyosarcoma in a patient with ulcerative colitis, emphasizing the need for vigilance.
Area of Science:
- Gastroenterology
- Oncology
- Pathology
Background:
- Patients with chronic inflammatory bowel disease (IBD) have an elevated risk of colorectal cancer, typically adenocarcinomas.
- Malignant mesenchymal tumors are rare complications in IBD patients.
Observation:
- A 40-year-old woman with a 9-year history of ulcerative colitis developed a 2cm rectal tumor.
- The tumor infiltrated the rectal wall to the subserosa and showed fusiform cells with 5 mitoses per 10 fields (×400).
- Immunohistochemical analysis revealed expression of actin, desmin, and caldesmone.
Findings:
- This case represents an exceptional occurrence of rectal leiomyosarcoma in the context of ulcerative colitis.
- A literature review identified 2 cases of leiomyosarcoma associated with Crohn's disease and 3 with ulcerative colitis.
Implications:
- This report underscores the rare but potential risk of leiomyosarcoma in IBD patients.
- Further research may elucidate the specific mechanisms linking IBD and mesenchymal tumor development.
- Clinical vigilance for unusual tumor types in IBD patients is warranted.
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