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Updated: Sep 8, 2025

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Piezo channels in the urinary system.

Xu Li1, Junwei Hu1, Xuedan Zhao1

  • 1Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200032, China.

Experimental & Molecular Medicine
|June 14, 2022
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Summary
This summary is machine-generated.

Piezo channels are crucial mechanosensitive molecules. This review highlights their roles in the urinary system, guiding future clinical applications for urinary diseases.

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Area of Science:

  • Molecular Biology
  • Physiology
  • Biochemistry

Background:

  • Piezo channels (Piezo1 and Piezo2) are essential mechanosensitive molecules in mammals.
  • They convert mechanical stimuli into biological signals, regulating physiological processes via a unique propeller-shaped structure and gating mechanism.
  • Their roles in various human systems are recognized, but understanding of their modulators is limited.

Purpose of the Study:

  • To systematically review the current evidence on Piezo channel structure, mechanogating, and pharmacology.
  • To focus on the physiological and pathophysiological roles of Piezo channels within the urinary system.
  • To identify future directions for clinical applications in urinary system diseases.

Main Methods:

  • Systematic literature review of Piezo channel research.
  • Analysis of studies focusing on Piezo channel function in mammalian systems.
  • Synthesis of evidence related to urinary system physiology and pathology.

Main Results:

  • Piezo channels possess a unique homotrimeric structure and gating mechanism.
  • Evidence increasingly supports the critical importance of Piezo channel function in the urinary system.
  • A gap exists in the comprehensive understanding of Piezo channel antagonists and agonists.

Conclusions:

  • Piezo channels are vital mechanotransducers with significant roles in the urinary system.
  • Further research into Piezo channel modulators is necessary.
  • This review provides a foundation for exploring clinical applications in urinary diseases.