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The impact of SARS-CoV-2 treatment on the cardiovascular system: an updated review

Mohammed Ahmed Akkaif1, Abubakar Sha'aban2, Arturo Cesaro3

  • 1School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800, Penang, Malaysia.

Inflammopharmacology
|June 14, 2022
PubMed

Insights

COVID-19 treatments can impact the cardiovascular system, especially in patients with pre-existing heart conditions. Careful consideration of drug interactions is crucial to prevent cardiac injury during COVID-19 treatment.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Pharmacology

Background:

  • The COVID-19 pandemic, caused by SARS-CoV-2, presents significant global health challenges.
  • Extrapulmonary effects of COVID-19, including cardiovascular involvement, are increasingly recognized.
  • Patients with underlying cardiovascular diseases face higher risks of severe illness and require tailored treatment.

Purpose of the Study:

  • To synthesize evidence on the cardiovascular impact of COVID-19 treatments.
  • To identify potential medication-induced cardiac injury in COVID-19 patients.
  • To inform optimized treatment strategies, particularly for vulnerable populations.

Main Methods:

  • Comprehensive literature search of databases until April 2022.
  • Inclusion of relevant studies, reviews, trials, and meta-analyses.
  • Analysis of reported impacts of SARS-CoV-2 treatments on the cardiovascular system.

Main Results:

  • COVID-19 negatively affects prognosis for patients with pre-existing cardiovascular disease.
  • Certain COVID-19 medications have been shown to interfere with cardiovascular function.
  • Risk of medication-induced cardiac injury is a concern, especially in elderly patients.

Conclusions:

  • COVID-19 treatment strategies must account for cardiovascular risks.
  • A thorough understanding of drug-cardiac system interactions is essential for safe and effective patient management.
  • Further research is needed to optimize COVID-19 therapies for cardiovascular safety.
Keywords:
COVID-19Cardiovascular diseasesDrug developmentSARS-CoV-2

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