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Intravital Microscopy of Tumor-associated Vasculature Using Advanced Dorsal Skinfold Window Chambers on Transgenic Fluorescent Mice
Published on: January 19, 2018
Nanoparticles mediated tumor microenvironment modulation: current advances and applications
Ganji Seeta Rama Raju1, Eluri Pavitra2, Ganji Lakshmi Varaprasad2
1Department of Energy and Materials Engineering, Dongguk University-Seoul, Seoul, 04620, Republic of Korea.
Abstract:
The tumor microenvironment (TME) plays a key role in cancer development and emergence of drug resistance. TME modulation has recently garnered attention as a potential approach for reprogramming the TME and resensitizing resistant neoplastic niches to existing cancer therapies such as immunotherapy or chemotherapy. Nano-based solutions have important advantages over traditional platform and can be specifically targeted and delivered to desired sites. This review explores novel nano-based approaches aimed at targeting and reprogramming aberrant TME components such as macrophages, fibroblasts, tumor vasculature, hypoxia and ROS pathways. We also discuss how nanoplatforms can be combined with existing anti-tumor regimens such as radiotherapy, immunotherapy, phototherapy or chemotherapy to enhance clinical outcomes in solid tumors.
Insights
Novel nano-based strategies can reprogram the tumor microenvironment (TME) to overcome cancer drug resistance. These nanoplatforms target aberrant TME components and enhance existing therapies like immunotherapy and chemotherapy for better clinical outcomes.
Area of Science:
- Oncology
- Nanomedicine
- Cancer Biology
Background:
- The tumor microenvironment (TME) is crucial in cancer progression and resistance to therapy.
- Modulating the TME is a promising strategy to resensitize tumors to treatments.
- Nanotechnology offers targeted delivery and TME reprogramming advantages.
Purpose of the Study:
- To review novel nano-based approaches for targeting and reprogramming the TME.
- To explore nanoplatforms for overcoming drug resistance in solid tumors.
- To discuss combinations of nanomedicine with standard cancer therapies.
Main Methods:
- Literature review of nano-based strategies targeting TME components.
- Analysis of nanoplatforms for reprogramming macrophages, fibroblasts, vasculature, hypoxia, and ROS.
- Examination of combination therapies involving nanomedicine and conventional treatments.
Main Results:
- Nanoparticles can effectively target and modulate key TME elements.
- Reprogramming the TME with nanomedicine enhances sensitivity to immunotherapy and chemotherapy.
- Combinatorial approaches show potential for improved clinical outcomes in solid tumors.
Conclusions:
- Nano-based solutions represent a powerful tool for TME modulation.
- Targeting the TME with nanomedicine can overcome drug resistance.
- Combining nanoplatforms with existing therapies offers a promising strategy for solid tumor treatment.
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