Related Experiment Video
Updated: Sep 8, 2025

Testing the In Vitro and In Vivo Efficiency of mRNA-Lipid Nanoparticles Formulated by Microfluidic Mixing
Published on: January 20, 2023
Recent advances in mRNA-LNP therapeutics: immunological and pharmacological aspects
Seyed Hossein Kiaie1,2,3, Naime Majidi Zolbanin4,5, Armin Ahmadi6
1Department of Formulation Development, ReNAP Therapeutics, Tehran, Iran.
Abstract:
In the last decade, the development of messenger RNA (mRNA) therapeutics by lipid nanoparticles (LNP) leads to facilitate clinical trial recruitment, which improves the efficacy of treatment modality to a large extent. Although mRNA-LNP vaccine platforms for the COVID-19 pandemic demonstrated high efficiency, safety and adverse effects challenges due to the uncontrolled immune responses and inappropriate pharmacological interventions could limit this tremendous efficacy. The current study reveals the interplay of immune responses with LNP compositions and characterization and clarifies the interaction of mRNA-LNP therapeutics with dendritic, macrophages, neutrophile cells, and complement. Then, pharmacological profiles for mRNA-LNP delivery, including pharmacokinetics and cellular trafficking, were discussed in detail in cancer types and infectious diseases. This review study opens a new and vital landscape to improve multidisciplinary therapeutics on mRNA-LNP through modulation of immunopharmacological responses in clinical trials.
Related Concept Videos
Microorganisms in Medicine and Therapeutics
lncRNA - Long Non-coding RNAs
Leaky Scanning
Experimental RNAi
Inflammatory Bowel Disease IV: Pharmacological Management
Pharmacologic...
Regulation of Expression Occurs at Multiple Steps
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...

