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Updated: Sep 8, 2025
07:15
An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota
Published on: July 31, 2019
9.7K
Gut microbiota, bile acids, and nature compounds.
Hao Cheng1, Juan Liu1, Dandan Zhang1
1State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Phytotherapy Research : PTR
|June 14, 2022
Summary
Natural compounds (NPs) interact with gut microbiota, influencing their metabolism and composition. This interaction affects bile acid (BA) metabolism, impacting disease progression and therapeutic efficacy of NPs.
Area of Science:
- Pharmacology
- Microbiology
- Metabolomics
Background:
- Natural compounds (NPs) are crucial in drug discovery and pharmacotherapy.
- Gut microbiota significantly influences NP efficacy through metabolism and compositional changes.
- Bile acids (BAs), key gut metabolites, play roles in homeostasis and disease development.
Purpose of the Study:
- To comprehensively review the intricate interactions among NPs, gut microbiota, and BAs.
- To elucidate the role of microbial BA metabolism in NP toxicity and efficacy.
- To provide insights into future research directions for NPs and BAs.
Main Methods:
- Literature review and synthesis of existing research on NP-microbiota-BA interactions.
- Analysis of studies detailing microbial metabolism of NPs and BAs.
- Discussion of experimental and computational approaches in the field.
Main Results:
- Gut microbiota metabolize NPs, altering their pharmacological activity.
- NPs modulate gut microbiota composition and function, including BA metabolism.
- Microbial BA metabolism is a critical factor in determining NP efficacy and toxicity.
Conclusions:
- Understanding the NP-gut microbiota-BA axis is essential for optimizing NP-based therapies.
- Targeting microbial BA metabolism offers novel therapeutic strategies.
- Further research is needed to fully harness the potential of this complex interplay.
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