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Corneal Confocal Microscopy: A Novel Non-invasive Technique to Quantify Small Fibre Pathology in Peripheral Neuropathies

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Small-Fiber Neuropathy Possibly Associated with COVID-19.

Ahmet Z Burakgazi^1,2

¹Department of Neurology, Brown University, Providence, Rhode Island, USA.

Case Reports in Neurology

|June 15, 2022

Summary

COVID-19 can affect the peripheral nervous system, potentially causing small-fiber neuropathy (SFN). This report highlights two cases, suggesting further investigation for neurological symptoms post-COVID-19 infection is warranted.

Keywords:

Case report Coronavirus disease 2019 Polyneuropathy Skin biopsy Small-fiber neuropathy

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Three-dimensional Imaging of Nociceptive Intraepidermal Nerve Fibers in Human Skin Biopsies

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Published on: April 29, 2013

Area of Science:

Neurology
Infectious Diseases
Peripheral Nervous System Disorders

Background:

COVID-19 is known to cause neurological complications affecting both central and peripheral nervous systems.
Research on COVID-19's impact on the peripheral nervous system (PNS) remains limited.
Diagnosing PNS complications can be challenging due to limited access to specialized evaluations.

Observation:

This report details two cases presenting with symptoms suggestive of small-fiber neuropathy (SFN).
These cases occurred in the context of or following COVID-19 infection.
Paresthesia (tingling or numbness) was a key symptom observed in these patients.

Findings:

The presented cases suggest a potential association between COVID-19 infection and the development of small-fiber neuropathy (SFN).
The findings underscore the need for increased clinical awareness regarding this possible complication.
Diagnostic methods like nerve conduction studies and skin biopsies may be crucial for confirming SFN in post-COVID-19 patients.

Implications:

Increased consideration of SFN in patients experiencing paresthesia during or after COVID-19 infection is recommended.
Further research is warranted to elucidate the neuropathological mechanisms underlying COVID-19-related SFN.
Investigating the efficacy of immunomodulatory treatments, such as intravenous immunoglobulin, for COVID-19-associated SFN is crucial.