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A Human Ex Vivo Atherosclerotic Plaque Model to Study Lesion Biology
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Inflammatory Factors Driving Atherosclerotic Plaque Progression New Insights

Boce Song1, Yulong Bie1, Haoxin Feng1

  • 1Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 10091, China.

Journal of Translational Internal Medicine
|June 15, 2022
PubMed

Insights

Coronary atherosclerosis involves chronic inflammation, with immune cells like macrophages driving lesion development through various stages. Understanding these inflammatory cell dynamics offers new insights into cardiovascular disease mechanisms.

Area of Science:

  • Cardiovascular Science
  • Immunology
  • Pathophysiology

Background:

  • Coronary atherosclerosis is a chronic inflammatory disease underlying cardiovascular disease.
  • Inflammatory factors are integral to atherosclerotic lesion development.
  • Macrophages, T cells, and neutrophils are key players in atherosclerotic inflammation.

Purpose of the Study:

  • To explore the dynamic changes in inflammatory cells during different stages of atherosclerotic lesions.
  • To elucidate the mechanisms associated with these inflammatory cell alterations.
  • To provide novel clinical and bench insights into atherosclerosis mechanisms.

Main Methods:

  • Review of inflammatory cell roles in atherosclerosis.
  • Analysis of cellular changes across distinct lesion stages (early plaque, formation, rupture).
  • Discussion of underlying molecular and cellular mechanisms.

Main Results:

  • Inflammatory cells, including macrophages, T cells, and neutrophils, exhibit distinct roles and changes throughout atherosclerosis progression.
  • Specific inflammatory mechanisms are associated with early plaque development, plaque formation, and plaque rupture.
  • The evolutionary nature of lesions correlates with specific inflammatory cell activities.

Conclusions:

  • Inflammatory cell dynamics are critical throughout the pathogenesis of coronary atherosclerosis.
  • Targeting specific inflammatory pathways or cells at different stages may offer therapeutic potential.
  • A comprehensive understanding of inflammatory cell behavior is crucial for advancing atherosclerosis research and treatment.

Keywords:
atherosclerosisby stageinflammation

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