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Updated: Sep 8, 2025

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Risk-Adjusted Cancer Screening and Prevention (RiskAP): Complementing Screening for Early Disease Detection by a

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Risk-adjusted cancer prevention utilizes individual risk prediction for better outcomes. This concept ensures timely, evidence-based interventions are available and continuously improved through evaluation.

Keywords:
Breast cancerELSI ethical, legal, social implicationsEvidence-generating careRisk-adjusted prevention

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Area of Science:

  • Oncology
  • Preventive Medicine
  • Genetics

Background:

  • Risk-adjusted cancer screening and prevention is emerging due to advances in risk factor knowledge and individual risk prediction.
  • A significant knowledge gap exists between identifying increased cancer risk and proving the effectiveness of preventive interventions.
  • Genetic diagnostics exacerbate this gap by identifying risk early, creating demand for immediate action.

Purpose of the Study:

  • To propose a risk-adjusted prevention concept.
  • To address the gap between risk identification and effective preventive measures.
  • To discuss implementation requirements.

Main Methods:

  • Developing a risk-adjusted prevention concept based on current evidence.
  • Continuous evaluation through outcome assessment.
  • Incorporating structural, procedural, legal, and socioeconomic aspects.

Main Results:

  • The proposed concept aims to provide timely and appropriate preventive measures.
  • It emphasizes ongoing evaluation and improvement based on outcomes.
  • Implementation considerations are discussed.

Conclusions:

  • A structured risk-adjusted prevention concept is needed to bridge the evidence gap.
  • Continuous evaluation and adaptation are crucial for effective cancer prevention.
  • Addressing implementation challenges is key to successful adoption.