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Factors influencing death in COVID-19 patients treated in the ICU: a single-centre, cross-sectional study

Izabela Kokoszka-Bargieł1, Paweł Cyprys2, Patryk Madeja1

  • 1Department of Anesthesiology and Intensive Therapy, Provincial Specialist Hospital, Tychy, Poland.

Anaesthesiology Intensive Therapy
|June 15, 2022
PubMed

Insights

Severe COVID-19 patients in the ICU face high mortality. Low total protein, frailty, and elevated lactate levels upon admission are key predictors of death in these critical patients.

Area of Science:

  • Critical Care Medicine
  • Infectious Diseases
  • Epidemiology

Background:

  • Investigated factors influencing mortality in severe coronavirus disease 2019 (COVID-19) patients admitted to the intensive care unit (ICU).
  • Focused on a single-center study of 113 consecutive patients over one year in a dedicated COVID-19 hospital in Poland.

Purpose of the Study:

  • To identify variables independently associated with ICU death among severe COVID-19 patients.
  • To analyze pre-admission, admission, and treatment data to understand mortality predictors.

Main Methods:

  • Retrospective review of data from 113 severe COVID-19 patients admitted to the ICU.
  • Comprehensive comparison of clinical and laboratory variables between survivors and non-survivors.
  • Statistical analysis to identify independent factors influencing ICU mortality.

Main Results:

  • Overall ICU mortality was 64.6%.
  • Non-survivors were older and had higher Clinical Frailty Scores, APACHE II, and SAPS II scores.
  • Independent predictors of ICU death included low total protein (<2.0 ng/mL), elevated lactate (>2.0 mmol/L), and Clinical Frailty Score ≥5.

Conclusions:

  • Low total protein, frailty, and elevated lactate levels at ICU admission are significantly associated with increased risk of death in severe COVID-19 patients.
  • These factors can aid in risk stratification and management of critically ill COVID-19 patients.
Abstract

Keywords:
comorbiditiesintensive care unitmortality.COVID-19

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