Related Experiment Video
Updated: Sep 8, 2025
Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
Various Factors that are Causing Difference in Prevalence of Coronary Risk Factors among Siblings
Anter Preet1, Sandeep Chhabra2, Shibba T Chabbra3
1Student, Department of Medicine; Dayanand Medical College and Hospital, Unit-Hero DMC Heart Institute, Ludhiana, Punjab, India.
Insights
This study investigated coronary artery disease (CAD) risk factors in siblings. Key factors like residence, physical activity, and stress significantly correlate with increased CAD prevalence among siblings.
Area of Science:
- Cardiology
- Genetics
- Public Health
Background:
- Coronary artery disease (CAD) is a leading cause of cardiovascular disease (CVD).
- Understanding familial aggregation of CAD risk factors is crucial for targeted prevention strategies.
Purpose of the Study:
- To investigate the prevalence and correlation of various coronary risk factors among siblings.
- To identify factors contributing to differences in CAD risk within sibling pairs.
Main Methods:
- Cross-sectional study involving 100 pairs of siblings.
- Data collected from healthy individuals and their siblings attending outpatient departments.
- Analysis included factors such as residence, socioeconomic status, physical activity, stress, smoking, waist-to-hip ratio, and diabetes.
Main Results:
- Obesity prevalence was higher in urban siblings, though not statistically significant.
- A statistically significant correlation (p=0.02) was found between impaired fasting blood sugar/diabetes and urban residence.
- Stress levels showed a significant correlation with CAD findings.
Conclusions:
- Residence, socioeconomic class, physical activity, stress levels, smoking, waist-to-hip ratio, and diabetes are significantly correlated with increased CAD risk among siblings.
- These factors highlight potential areas for intervention in familial CAD prevention.
Background And Aim:
Coronary artery disease (CAD) is one of the predominant types of cardiovascular disease (CVD). The aim of present study was to study various factors that are causing difference in prevalence of coronary risk factors among siblings.
Materials And Methods:
This cross-sectional study was conducted in Dayanand Medical College and Hospital, among the healthy individuals (not known CAD) attending regular health care outpatient department (OPD) and their siblings over a period of 1½ years. All individuals coming for regular health checkup (not known CAD) of age more than 30 years or above and their siblings (with or without known CAD).
Results:
This was a cross-sectional study, conducted among 100 pairs of healthy siblings (not known cases of CAD) who came for health checkup at health center of Dayanand Medical College and Hospital, a tertiary care hospital in North India. Prevalence of obesity was more in siblings living in urban area than their counter siblings living in rural area, but it was statistically insignificant. Six had impaired fasting blood sugar (FBS) and two were diabetic. Among their siblings living in urban area, 21 were nondiabetic, 10 had impaired FBS, and seven were diabetic. This correlation was statistically significant with p-value of 0.02. Among the CAD negative, out of 23 subjects, two subjects (9.0%) had heavy stress level, while remaining four subjects (17.0%) and 17 subjects (74.0%) had light and moderate stress levels, respectively. Among the CAD negative, out of 23 subjects, 10 subjects (43.0%) had high stress level, while remaining zero subject (0%) and 13 subjects (57.0%) had light and moderate stress levels, respectively. Significant results were obtained while comparing the CAD findings of subjects divided on the basis of stress level.
Conclusion:
In our study, among siblings (CAD positive and CAD negative), significant results were obtained for residence, socioeconomic class, physical activity, stress levels, smoking, waist-to-hip ratio (WHR), and diabetes, that is, all these factors have correlation in increasing CAD among siblings.
More Related Videos
08:42Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research
Published on: October 22, 2014
05:31Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
Published on: August 7, 2017
Related Concept Videos
01:18Factors Affecting Illness
For instance, risk factors are connected to illness,...
01:30Coronary Artery Disease I: Introduction
01:26Factors Affecting the Risk of Infection
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
01:28Factors affecting Blood pressure
Physiological Factors:
01:12Relative Risk
01:30Factors Influencing Heart Rate
Let us explore the significant factors affecting heart rate, including age, body temperature, posture, acute pain, chemical influences,...