Related Experiment Video
Updated: Sep 8, 2025

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
A Multisite Collaborative to Decrease Inappropriate Antibiotics in Urgent Care Centers
Amanda Nedved1, Melody Fung2, Destani Bizune3
1Division of Urgent Care, Children's Mercy Kansas City, University of Missouri-Kansas City School of Medicine, Kansas City, Missouri.
Insights
Pediatric urgent care centers significantly reduced inappropriate antibiotic prescriptions by over 50% for common diagnoses. This quality improvement project demonstrates effective antibiotic stewardship in urgent care settings.
Area of Science:
- Pediatric Urgent Care
- Antibiotic Stewardship
- Quality Improvement
Background:
- Urgent care centers have high rates of inappropriate antibiotic prescribing.
- Pediatric urgent care antibiotic prescribing practices were previously unknown.
- A quality improvement project aimed to reduce inappropriate antibiotic use in pediatric urgent care.
Purpose of the Study:
- To decrease inappropriate antibiotic prescribing for acute otitis media, otitis media with effusion, and pharyngitis in pediatric urgent care centers.
- To achieve a relative 20% reduction in inappropriate antibiotic prescriptions by December 1, 2019.
Main Methods:
- A multisite quality improvement study involving pediatric urgent care clinicians.
- Utilized algorithms based on guidelines to identify inappropriate antibiotic prescriptions.
- Implemented interventions from antibiotic stewardship materials over multiple cycles.
Main Results:
- Overall inappropriate antibiotic prescription rates decreased by a relative 53.9% across 20 centers.
- Significant reductions observed for acute otitis media (57.0% to 36.6%), otitis media with effusion (54.6% to 48.4%), and pharyngitis (66.9% to 11.7%).
Conclusions:
- Pediatric urgent care providers reduced inappropriate antibiotic prescriptions from 60.3% to 27.8%.
- Publicly available antibiotic stewardship interventions were effective in improving prescribing practices.
Background:
Urgent care (UC; a convenient site to receive care for ambulatory-sensitive) centers conditions; however, UC clinicians showed the highest rate of inappropriate antibiotic prescriptions among outpatient settings according to national billing data. Antibiotic prescribing practices in pediatric-specific UC centers were not known but assumed to require improvement. The aim of this multisite quality improvement project was to reduce inappropriate antibiotic prescribing practices for 3 target diagnoses in pediatric UC centers by a relative 20% by December 1, 2019.
Methods:
The Society of Pediatric Urgent Care invited pediatric UC clinicians to participate in a multisite quality improvement study from June 2019 to December 2019. The diagnoses included acute otitis media (AOM), otitis media with effusion, and pharyngitis. Algorithms based on published guidelines were used to identify inappropriate antibiotic prescriptions according to indication, agent, and duration. Sites completed multiple intervention cycles from a menu of publicly available antibiotic stewardship materials. Participants submitted data electronically. The outcome measure was the percentage of inappropriate antibiotic prescriptions for the target diagnoses. Process measures were use of delayed antibiotics for AOM and inappropriate testing in pharyngitis.
Results:
From 20 UC centers, 157 providers submitted data from 3833 encounters during the intervention cycles. Overall inappropriate antibiotic prescription rates decreased by a relative 53.9%. Inappropriate antibiotic prescribing decreased from 57.0% to 36.6% for AOM, 54.6% to 48.4% for otitis media with effusion, and 66.9% to 11.7% for pharyngitis.
Conclusions:
Participating pediatric UC providers decreased inappropriate antibiotic prescriptions from 60.3% to 27.8% using publicly available interventions.
Related Concept Videos
Healthcare Associated Infections II: Preventive Measures
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care
Nursing Clinical Information System
A Nursing Clinical Information System (NCIS) is a specialized type of healthcare information system tailored to meet the unique needs of nursing practice. It incorporates the principles of nursing informatics to streamline information management and improve the quality of care delivery.
Critical attributes of NCIS include:
Acute Kidney Injury V: Interprofessional Care
Antibiotic Selection
Combined Effects of Drugs: Synergism
Such synergistic combinations...

