Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Sexually Transmitted Infections01:26

Sexually Transmitted Infections

410
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
410
Development of Immunocompetence01:22

Development of Immunocompetence

444
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
444
Rh Blood Group01:19

Rh Blood Group

1.8K
The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
1.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Physiological-Based Cord Clamping and Early Oxygenation in Newborns With Transposition of the Great Arteries: A Quality Improvement Study Protocol.

CJC pediatric and congenital heart disease·2026
Same author

Early impact of RSV prevention on infant hospitalisations in Denmark.

The Lancet regional health. Europe·2026
Same author

Individualised duration of antibiotic treatment in culture-negative early-onset sepsis in late-preterm and term-born neonates in Denmark (DURATION): a multicentre, open-label, randomised, controlled, non-inferiority trial.

The Lancet. Child & adolescent health·2026
Same author

Surfactant administration via supraglottic airway in premature infants (SALSA): a survey-based assessment of current procedural practice.

Archives of disease in childhood. Fetal and neonatal edition·2026
Same author

No Association Between Umbilical Cord pH and Special Educational Needs Among Children With Normal 5-Minute Apgar Scores.

Acta paediatrica (Oslo, Norway : 1992)·2026
Same author

Sepsis and Antibiotics in Extremely Preterm Infants: Early Empirical Treatment Was Common, While Late-Onset Sepsis Accounted for Most Cases and Antibiotic Use.

Acta paediatrica (Oslo, Norway : 1992)·2026

Related Experiment Video

Updated: Sep 8, 2025

Ex Vivo Infection of Murine Epidermis with Herpes Simplex Virus Type 1
11:56

Ex Vivo Infection of Murine Epidermis with Herpes Simplex Virus Type 1

Published on: August 24, 2015

11.3K

[Herpes simplex virus infection in newborns].

Stine Lund1, Tine Brink Henriksen2, Anja Poulsen3

  • 1Afdeling for Intensiv behandling af nyfødte og mindre børn, Københavns Universitets hospital - Rigshospitalet.

Ugeskrift for Laeger
|June 15, 2022
PubMed
Summary

Neonatal herpes simplex virus (HSV) infection is a serious threat to newborns, with rising incidence but unchanged mortality. Early diagnosis and antiviral treatment, including suppressive therapy, are crucial for improving outcomes.

More Related Videos

Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain
05:51

Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain

Published on: July 24, 2016

19.8K
A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation
12:22

A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation

Published on: April 2, 2012

17.5K

Related Experiment Videos

Last Updated: Sep 8, 2025

Ex Vivo Infection of Murine Epidermis with Herpes Simplex Virus Type 1
11:56

Ex Vivo Infection of Murine Epidermis with Herpes Simplex Virus Type 1

Published on: August 24, 2015

11.3K
Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain
05:51

Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain

Published on: July 24, 2016

19.8K
A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation
12:22

A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation

Published on: April 2, 2012

17.5K

Area of Science:

  • Neonatal infectious diseases
  • Virology
  • Public health

Background:

  • Neonatal herpes simplex virus (HSV) infection is a rare, severe condition with significant morbidity and mortality.
  • Incidence of neonatal HSV has increased in recent decades, while mortality rates remain static.
  • Effective management hinges on prompt recognition and intervention.

Purpose of the Study:

  • To review current evidence on risk factors, clinical presentation, prevention, and management of neonatal HSV.
  • To highlight the importance of early diagnosis and treatment for improving infant outcomes.
  • To discuss the role of suppressive antiviral therapy in long-term prognosis.

Main Methods:

  • Comprehensive literature review of studies on neonatal herpes simplex disease.
  • Synthesis of evidence regarding risk factors, clinical manifestations, and epidemiological trends.
  • Analysis of treatment strategies, including acute parenteral and long-term suppressive antiviral therapies.

Main Results:

  • Early clinical suspicion and prompt parenteral antiviral treatment are critical for neonatal HSV prognosis.
  • Suppressive oral acyclovir therapy significantly improves long-term outcomes for affected infants.
  • Despite advances, mortality rates for neonatal HSV have not decreased, underscoring the need for improved prevention and management.

Conclusions:

  • Timely diagnosis and aggressive antiviral treatment are paramount in managing neonatal HSV.
  • Suppressive therapy with oral acyclovir offers a valuable strategy for enhancing long-term infant health.
  • Continued research and public health efforts are needed to address the persistent mortality associated with this infection.