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Hypersensitivity Reaction to Carbon Fiber-Polyetheretherketone Composite Spinal Implant: A Case Report

Brian T Bueno1,2, Mark Henry1, Samuel K Cho1

  • 1Department of Orthopedics, Icahn School of Medicine at Mount Sinai, New York, New York.

JBJS Case Connector
|June 15, 2022
PubMed
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Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum...
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