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Improved Home Blood Pressure Control by CT-guided Ozone-mediated Renal Denervation for Patients with Resistant Hypertension
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Lifestyle modification and cognitive function among individuals with resistant hypertension: cognitive outcomes from

Patrick J Smith1, Andrew Sherwood1, Alan L Hinderliter2

  • 1Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham.

Journal of Hypertension
|June 15, 2022
PubMed

Insights

Lifestyle modification in patients with resistant hypertension improved cognitive function, particularly executive function. These cognitive gains were linked to weight loss and improved vascular health, suggesting a pathway for preserving brain health.

Area of Science:

  • Cardiology
  • Neurology
  • Vascular Biology

Background:

  • Resistant hypertension increases the risk of cognitive decline, stroke, and dementia.
  • Lifestyle modifications may enhance cognitive function by positively impacting vascular health.

Purpose of the Study:

  • To investigate the effects of a cardiac rehabilitation-based lifestyle program (C-LIFE) on cognitive function in patients with resistant hypertension.
  • To explore the relationship between lifestyle interventions, cognitive performance, and vascular biomarkers.

Main Methods:

  • 140 patients with resistant hypertension were randomized to either the C-LIFE program or a standard education and physician advice (SEPA) group.
  • Cognitive function was assessed using tests of Executive Functioning, Learning, Memory, and Processing Speed.
  • Biomarkers of vascular function (FMD, microvascular, cerebrovascular), weight, fitness, and ambulatory blood pressure were measured.

Main Results:

  • The C-LIFE group showed significant improvements in Executive Function/Learning compared to the SEPA group.
  • Cognitive improvements were moderated by sex and baseline stroke risk.
  • The C-LIFE intervention led to improvements in flow-mediated dilation (FMD) and microvascular function, but not cerebrovascular reactivity.
  • Weight loss-induced reduction in systolic blood pressure (SBP) was associated with enhanced executive function/learning.

Conclusions:

  • Lifestyle modification in resistant hypertension patients improves cognition, potentially mediated by weight loss and reduced SBP.
  • Cognitive enhancements correlate with improvements in endothelial and microvascular function.
Abstract

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