Iodine(III) reagents for oxidative aromatic halogenation.

Area of Science:

• Organic Chemistry
• Synthetic Chemistry
• Green Chemistry

Background:

• Iodine(III) reagents are recognized for their safety, non-toxicity, and ease of handling.
• They serve as effective alternatives to hazardous reagents and harsh reaction conditions in organic synthesis.
• Their oxidizing properties are valuable for modifying various chemical structures.

Purpose of the Study:

• To review representative procedures utilizing iodine(III) reagents for functionalizing aryl and heteroaryl compounds.
• To emphasize the introduction of halogens and other non-aromatic groups.
• To showcase the versatility and green aspects of iodine(III) chemistry.

Main Methods:

• Literature review of developed procedures involving iodine(III) reagents.
• Focus on metal-free transformations and functionalization strategies.
• Analysis of halogen introduction into aromatic and heteroaromatic systems.

Main Results:

• Iodine(III) reagents facilitate the functionalization of diverse aromatic and heteroaromatic cores.
• Successful introduction of halogens and other non-aromatic groups has been demonstrated.
• Metal-free arylation and other transformations are well-documented.

Conclusions:

• Iodine(III) reagents are versatile, safe, and green tools in organic synthesis.
• They provide efficient methods for halogenation and other functionalizations of (hetero)aromatic systems.
• Their application represents a significant advancement over traditional hazardous methods.