Related Experiment Video

Updated: Sep 8, 2025

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

5.4K

Relationship between Systemic Immune-Inflammation Index and Coronary Collateral Circulation in Patients with Chronic

Mehmet Koray Adali1, Ipek Buber1, Gursel Sen1

  • 1Pamukkale University - Faculty of Medicine, Departamento de Cardiologia, Denizli - Turquia.

Arquivos Brasileiros De Cardiologia
|June 15, 2022
PubMed

Insights

High systemic immune-inflammation index (SII) is linked to poor coronary collateral circulation (CCC) in stable coronary artery disease (CAD) patients. This finding may help predict CAD prognosis using readily available inflammatory markers.

Area of Science:

  • Cardiology
  • Immunology
  • Biomarkers

Background:

  • Inflammation is crucial in coronary artery disease (CAD) development and progression.
  • The systemic immune-inflammation index (SII) is an emerging inflammatory marker associated with CAD.

Purpose of the Study:

  • To investigate the association between SII and coronary collateral circulation (CCC) in patients with stable CAD and chronic total occlusion (CTO).

Main Methods:

  • Patients were classified into poor CCC (n=94) and good CCC (n=81) groups based on Rentrop Classification.
  • Inflammatory parameters, including SII, were analyzed from laboratory results.
  • Statistical analysis determined significant associations with a significance level of 0.05.

Main Results:

  • High SII levels (OR: 1.003, p<0.001), absence of CTO in the right coronary artery (OR: 0.204, p<0.001), and low Gensini score (OR: 0.980, p=0.028) were significantly associated with poor CCC.
  • An SII cutoff of 679.96 demonstrated the highest predictive power for poor CCC (sensitivity 74.5%, specificity 43.2%).
  • No significant difference in mortality rates was observed between groups during follow-up (p=0.107).

Conclusions:

  • High SII levels, absence of CTO in the right coronary artery, and low Gensini score are significantly related to poor CCC.
  • The study highlights the potential of SII as a prognostic marker in CAD.
  • Rapid and cost-effective inflammatory markers like SII can guide CAD prognosis in clinical practice.
Abstract

More Related Videos

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts08:51

Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts

Published on: September 20, 2024

1.5K
Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression13:07

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

Published on: January 15, 2022

4.0K

Related Concept Videos

Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
28
Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
33
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
23
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
45
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
54
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
31