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Efficacy of Oral vs. Intravenous Calcium Supplementation for Continuation Therapy in Hypocalcemic Seizures: A

Himanshu Dhir1, Deepak Kumar1, Dheeraj Shah1

  • 1Department of Pediatrics, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, 110095, India.

Indian Journal of Pediatrics
|June 15, 2022
PubMed

Insights

Oral calcium is as effective as intravenous calcium for treating hypocalcemic seizures in children. This study found comparable seizure recurrence rates and serum calcium levels between the two treatment groups.

Area of Science:

  • Pediatric Neurology
  • Clinical Pharmacology
  • Biochemistry

Background:

  • Hypocalcemic seizures are a critical condition in children.
  • Intravenous calcium is the standard for initial treatment.
  • The optimal route for continuation therapy remains under investigation.

Purpose of the Study:

  • To compare the efficacy of oral versus intravenous calcium supplementation for continuation therapy in children with hypocalcemic seizures.
  • To evaluate seizure recurrence and serum calcium levels in both treatment arms.

Main Methods:

  • A randomized controlled trial involving 60 children (1 month to 5 years) with hypocalcemic seizures.
  • Participants received either intravenous calcium gluconate or oral elemental calcium for 48 hours post-initial seizure control.
  • Seizure recurrence and serum calcium levels were monitored.

Main Results:

  • Seizure recurrence rates were similar: 10% in the intravenous group and 13.3% in the oral group (p=0.278).
  • Serum calcium levels at 24 and 48 hours were comparable between the intravenous and oral calcium groups.
  • No significant differences were observed in key efficacy parameters.

Conclusions:

  • Oral calcium supplementation appears to be as efficacious as intravenous calcium during the continuation phase of treating hypocalcemic seizures in children.
  • Further research is warranted to establish definitive treatment guidelines.
Abstract

Keywords:
CalciumHypocalcemiaSeizuresTherapy

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