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A long noncoding RNA promotes parasite differentiation in African trypanosomes

Fabien Guegan1, K Shanmugha Rajan2, Fábio Bento1

  • 1Instituto de Medicina Molecular-Joao Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal.

Science Advances
|June 15, 2022
PubMed
Summary

A newly discovered long noncoding RNA, grumpy, regulates Trypanosoma brucei differentiation into stumpy forms. Overexpressing grumpy reduces parasite levels in mice, offering a potential therapeutic target for African sleeping sickness.

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