Related Experiment Video
Updated: Sep 8, 2025

Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method
Published on: April 18, 2019
Simple Dipyrrin Analogues of Prodigiosin for Use as Colistin Adjuvants
Kittipan Siwawannapong1, Ansley M Nemeth2, Roberta J Melander2
1Department of Chemistry, North Carolina State University, Raleigh, NC 27695, USA.
Abstract:
Multidrug resistant (MDR) bacteria are an increasing public health problem. One promising alternative to the development of new antibiotics is the use of antibiotic adjuvants, which would allow the continued use of FDA-approved antibiotics that have been rendered ineffective due to resistance. Herein, we report a series of dipyrrins and pyrrole derivatives designed as analogues of prodigiosin and obatoclax, several of which potentiate the activity of colistin against Klebsiella pneumoniae, with lead compounds also potentiating colistin against Acinetobacter baumannii and Pseudomonas aeruginosa.
Related Concept Videos
Combined Effects of Drugs: Synergism
Such synergistic combinations...
Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
Antibiotic Selection
Drugs that Destabilize Microtubules
Colloidal precipitates
Prodrugs
Prodrugs help overcome...

