Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Mechanical Ventilation II: Invasive Ventilation

Mechanical Ventilation II: Invasive Ventilation

Ventilators are essential medical equipment used to aid patients with respiratory difficulties. Their primary function is to assist or replace spontaneous breathing by providing mechanical ventilation. There are two general classes of mechanical ventilators: negative-pressure and positive-pressure ventilators.
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Protocol for simultaneous non-invasive electrocardiogram and respiratory plethysmography recordings in mice.

STAR protocols·2026

Same author

The protective effect of cutaneous vagus nerve stimulation from necrotizing enterocolitis (NEC) in neonatal rats.

Pediatric research·2026

Same author

Neuromuscular and neuromechanical assessments of respiratory performance in the mdx mouse model of Duchenne muscular dystrophy across the natural history of disease.

Experimental physiology·2026

Same author

Neonatally-derived multipotent Islet-1+ Mesp1+FOXA2+ stem cell clones restore cardiac function in sheep.

Frontiers in cardiovascular medicine·2026

Same author

Comparison of Intraneural Facilitation<sup>TM</sup> Therapy and Exercise on Patients with Type 2 Diabetes: A Single-Blind Randomized Trial.

Biomedicines·2025

Same author

Withdrawal of Life-Sustaining Treatment in Children Managed in Nine PICUs in the United States: A Secondary Analysis of the Death One Hour After Terminal Extubation (DONATE) Dataset, 2009-2021.

Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·2025

Search research articles

Related Experiment Video

Updated: Sep 8, 2025

Method of Isolated Ex Vivo Lung Perfusion in a Rat Model: Lessons Learned from Developing a Rat EVLP Program

Method of Isolated Ex Vivo Lung Perfusion in a Rat Model: Lessons Learned from Developing a Rat EVLP Program

Published on: February 25, 2015

Comparison of Local and Systemic Inflammation During Invasive Versus Noninvasive Ventilation in Rats.

Billy C Wang¹, Richard P Lion², Michael Avesar³

¹Division of Pediatric Critical Care Medicine, Department of Pediatrics, OSF Children's Hospital of Illinois, Peoria, Illinois, USA.

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research

|June 15, 2022

Summary

Noninvasive ventilation (NIV) and invasive mechanical ventilation (IMV) showed similar effects on inflammation. However, NIV significantly reduced local lung inflammation in rats with lung injury, unlike IMV.

Keywords:

cytokines inflammation mechanical ventilation noninvasive ventilation ventilator-induced lung injury

More Related Videos

A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats

A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats

Published on: February 20, 2021

A Mouse Model of Orotracheal Intubation and Ventilated Lung Ischemia Reperfusion Surgery

A Mouse Model of Orotracheal Intubation and Ventilated Lung Ischemia Reperfusion Surgery

Published on: September 9, 2022

Related Experiment Videos

Last Updated: Sep 8, 2025

Method of Isolated Ex Vivo Lung Perfusion in a Rat Model: Lessons Learned from Developing a Rat EVLP Program

Method of Isolated Ex Vivo Lung Perfusion in a Rat Model: Lessons Learned from Developing a Rat EVLP Program

Published on: February 25, 2015

A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats

A Reproducible Intensive Care Unit-Oriented Endotoxin Model in Rats

Published on: February 20, 2021

A Mouse Model of Orotracheal Intubation and Ventilated Lung Ischemia Reperfusion Surgery

A Mouse Model of Orotracheal Intubation and Ventilated Lung Ischemia Reperfusion Surgery

Published on: September 9, 2022

Area of Science:

Pulmonary Medicine
Critical Care Medicine
Inflammation Research

Background:

The inflammatory impact of noninvasive ventilation (NIV) versus invasive mechanical ventilation (IMV) is not well understood.
Quantifying local and systemic inflammation is crucial for comparing respiratory support strategies.

Purpose of the Study:

To compare the effects of NIV and IMV on local and systemic inflammation in rats with lipopolysaccharide (LPS)-induced lung injury.
To evaluate inflammatory responses in healthy rats under NIV and IMV.

Main Methods:

Rats with LPS-induced lung injury and healthy rats were subjected to 4 hours of NIV, IMV, or control (spontaneously breathing).
Cytokine levels in serum and lung tissue were measured using multiplex enzyme-linked immunosorbent assay.

Main Results:

No significant differences in serum or lung cytokine levels were observed between NIV and IMV groups in either LPS-injured or healthy rats.
In LPS-injured rats, NIV treatment significantly reduced pulmonary levels of IL-1α, IL-6, and TNF-α compared to controls.
IMV treatment did not show a significant reduction in these pulmonary cytokines compared to controls in LPS-injured rats.

Conclusions:

Noninvasive ventilation, unlike invasive mechanical ventilation, demonstrated an ability to attenuate local pulmonary inflammation in an LPS-induced lung injury model.
NIV may offer a localized anti-inflammatory benefit in certain lung injury scenarios.