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Staphylococcus aureus adhesion to the host

Kirsten A Berry1, Mackenzie T A Verhoef1, Allison C Leonard1

  • 1Department of Molecular and Cellular Biology, College of Biological Sciences, University of Guelph, Guelph, Ontario, Canada.

Annals of the New York Academy of Sciences
|June 15, 2022
PubMed

Insights

Staphylococcus aureus uses diverse adhesins to colonize and infect humans. Targeting these adhesins offers a promising antivirulence strategy against antimicrobial resistance.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Drug Discovery

Background:

  • Staphylococcus aureus is a versatile pathobiont causing diverse human infections.
  • Host adhesion is critical for S. aureus colonization and infection establishment.
  • The pathogen possesses a wide array of adhesins contributing to its success.

Purpose of the Study:

  • To review S. aureus adhesin classes and their roles in various infections.
  • To explore adhesion sites and associated clinical outcomes.
  • To identify novel therapeutic targets for S. aureus decolonization and antivirulence.

Main Methods:

  • Literature review of S. aureus adhesins.
  • Analysis of host-pathogen interactions.
  • Evaluation of potential therapeutic targets.

Main Results:

  • Detailed classification of S. aureus adhesins.
  • Correlation of specific adhesins with infection sites and clinical manifestations.
  • Identification of adhesion-associated targets for therapeutic intervention.

Conclusions:

  • S. aureus adhesins are key virulence factors.
  • Targeting host-pathogen interactions presents an alternative to traditional antibiotics.
  • Adhesion-associated antivirulence strategies show potential for combating S. aureus infections.
Keywords:
MRSAStaphylococcus aureusadhesinscolonizationhost adhesioninfections

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