Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Heart Failure I: Introduction01:27

Heart Failure I: Introduction

49
Heart failure refers to a clinical syndrome caused by structural or functional cardiac disorders that prevent the heart from pumping an adequate amount of blood to meet the body's metabolic needs. This condition often arises from myocardial infarction or ischemia, leading to decreased cardiac output, reduced tissue perfusion, impaired gas exchange, fluid volume imbalance, and decreased functional ability.Heart failure can result from disruptions in the mechanisms that regulate cardiac output...
49
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

1.8K
Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.8K
Heart Failure IV: Classification and Diagnostic Evaluation01:30

Heart Failure IV: Classification and Diagnostic Evaluation

29
Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
29
Obesity01:24

Obesity

609
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
609
Heart Failure VI: Adjunct Therapies01:22

Heart Failure VI: Adjunct Therapies

26
Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
26
Heart Failure VII: Nursing Interventions01:30

Heart Failure VII: Nursing Interventions

137
The first step in nursing management of a patient with heart failure involves thoroughly assessing the patient's medical history.Subjective Data: Obtain the patient's medical history of coronary artery disease, hypertension, myocardial infarction, and symptoms like dyspnea, orthopnea, and paroxysmal nocturnal dyspnea.Objective Data: Conduct a physical examination to identify findings such as jugular vein distention, pulmonary crackles, tachycardia, murmurs, peripheral edema, and vital signs,...
137

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Late-Presenting Fulminant Immune Checkpoint Inhibitor Myocarditis Managed With Abatacept and Venoarterial Extracorporeal Oxygenation.

JACC. Case reports·2026
Same author

Advanced Imaging in Loeffler Endocarditis in the Setting of Dupilumab-Associated Hypereosinophilia: Diagnostic Utility of Cardiac MRI.

Circulation. Cardiovascular imaging·2026
Same author

Lipoprotein(a) in selected autoimmune diseases: A systematic review of cardiovascular implications and anti-inflammatory interventions.

Journal of clinical lipidology·2026
Same author

Assessment of ChatGPT-4.0 versus ChatGPT-Mini in Generating Guideline-Based Hypertension Content.

Arquivos brasileiros de cardiologia·2026
Same author

Epicardial Adipose Tissue, Coronary Plaque Progression, and Major Adverse Cardiovascular Events: A Multicenter Study.

JACC. Cardiovascular imaging·2026
Same author

Residual inflammatory risk and clinical outcomes after contemporary percutaneous coronary intervention: a systematic review and meta-analysis.

Scientific reports·2026

Related Experiment Video

Updated: Sep 8, 2025

Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF
03:42

Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF

Published on: March 29, 2024

1.6K

Severe Obesity and Heart Failure.

Jose S Aguilar-Gallardo1, Francisco Jose Romeo1, Kirtipal Bhatia2

  • 1Department of Medicine, Mount Sinai Morningside, Icahn Shool of Medicine at Mount Sinai. New York, NY.

The American Journal of Cardiology
|June 15, 2022
PubMed
Summary

The obesity paradox, where obesity reduces mortality in heart failure (HF) patients, was studied. Severe obesity did not show reduced mortality, unlike nonsevere obesity, indicating a U-shaped relationship for HF mortality.

More Related Videos

Multidisciplinary Approach to Obesity Management: A Case Report
05:10

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

346
A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats
07:31

A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats

Published on: December 2, 2016

10.1K

Related Experiment Videos

Last Updated: Sep 8, 2025

Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF
03:42

Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF

Published on: March 29, 2024

1.6K
Multidisciplinary Approach to Obesity Management: A Case Report
05:10

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

346
A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats
07:31

A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats

Published on: December 2, 2016

10.1K

Area of Science:

  • Cardiology
  • Obesity Medicine
  • Health Services Research

Background:

  • The obesity paradox suggests reduced mortality in overweight/obese patients with certain chronic conditions, including heart failure (HF).
  • The relationship between severe obesity and mortality/secondary outcomes in hospitalized HF patients requires further investigation.

Purpose of the Study:

  • To investigate the obesity paradox in severe obesity for hospitalized heart failure patients.
  • To examine the association between obesity severity and secondary outcomes like length of stay, total charges, and cardiogenic shock.

Main Methods:

  • Retrospective cohort study using the 2017-2018 National Inpatient Sample.
  • Inclusion of adult patients hospitalized for heart failure, categorized by obesity status (severe, nonsevere, none).
  • Multivariate regression analysis adjusted for demographics and comorbidities to assess primary outcome (mortality) and secondary outcomes.

Main Results:

  • Nonsevere obesity was associated with reduced mortality (OR 0.74), confirming the obesity paradox.
  • Severe obesity was not associated with reduced mortality (OR 1.01), suggesting a U-shaped mortality curve.
  • Both severe and nonsevere obesity were linked to increased length of stay and reduced cardiogenic shock; severe obesity also correlated with higher total charges.

Conclusions:

  • A nonlinear, U-shaped relationship exists between obesity and mortality in hospitalized HF patients.
  • Severe obesity, unlike nonsevere obesity, does not confer a survival benefit and is associated with worse secondary outcomes.
  • Further research using models like the adiposity-based chronic disease model is needed to understand complex obesity-related outcomes in HF.