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Updated: Sep 8, 2025
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Contact-Free Co-Culture Model for the Study of Innate Immune Cell Activation During Respiratory Virus Infection
Published on: February 28, 2021
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A prolonged innate systemic immune response in COVID-19
Sandra Ekstedt1, Krzysztof Piersiala2, Marianne Petro1
1Division of ENT Diseases, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden.
Scientific Reports
|June 15, 2022
Summary
COVID-19 alters neutrophil phenotypes, impacting immune responses. Understanding these changes in neutrophil activation and maturity is crucial for developing new COVID-19 therapies targeting severe disease.
Area of Science:
- Immunology
- Pathophysiology
Background:
- COVID-19 remains a global health challenge requiring novel therapeutic strategies.
- Neutrophils are early responders to inflammation and play a key role in COVID-19 pathogenesis.
Purpose of the Study:
- To investigate neutrophil phenotypes in COVID-19 patients.
- To analyze markers of neutrophil migration, maturity, activation, and granule content.
Main Methods:
- Utilized flow cytometry to measure neutrophil surface and intracellular markers.
- Compared neutrophil phenotypes between COVID-19 patients and healthy individuals.
Main Results:
- Neutrophils in COVID-19 patients exhibit distinct phenotypes compared to healthy controls.
- Elevated neutrophil activation, including NETs production, and prolonged maturity were observed.
- Alterations in granule content suggest impaired neutrophil function.
Conclusions:
- Neutrophils display significant phenotypic changes during COVID-19 infection.
- These altered neutrophil characteristics may contribute to severe COVID-19 outcomes.
- Further understanding of neutrophil roles is essential for targeted COVID-19 treatments.
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