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Platelet distribution width associated with short-term prognosis and cost in paediatrics with partial-thickness

Hailiang Liu1, Dongjie Li1, Tianjun Sun1

  • 1From Department of Burns and Plastic Surgery, The Forth Medical Center, Chinese PLA General Hospital, Beijing, China.

International Wound Journal
|June 16, 2022
PubMed

Insights

Platelet distribution width (PDW) can predict faster wound healing and lower medical costs in children with partial-thickness thermal burns. Higher PDW levels indicate a better short-term prognosis for pediatric burn patients.

Area of Science:

  • Pediatric Burn Care
  • Hematology
  • Wound Healing Research

Background:

  • Platelets play a crucial role in burn wound healing, inflammation, and tissue repair.
  • Platelet distribution width (PDW) reflects platelet size, morphology, and activation status.

Purpose of the Study:

  • To evaluate the predictive value of PDW for short-term prognosis in pediatric patients with partial-thickness thermal burns.
  • To assess the correlation between PDW levels and wound healing rates, duration, and healthcare costs.

Main Methods:

  • Retrospective study of 73 pediatric patients with partial-thickness thermal burns.
  • Receiver operating characteristic (ROC) curve analysis to determine the optimal PDW cut-off value.
  • Comparison of wound healing outcomes, in-hospital costs, and length of stay between high and low PDW groups.
  • Univariate and multivariate logistic regression analyses to identify PDW as an independent predictor.

Main Results:

  • High PDW group showed a significantly higher 2-week wound healing rate (66.7% vs. 32.6%, P < .01).
  • Mean time to wound healing was shorter in the high PDW group (15.4 days vs. 20.7 days, P = .04).
  • PDW was confirmed as an independent marker for wound healing (Univariate OR: 0.24, Multivariate OR: 0.15).
  • High PDW group experienced lower in-hospital costs (P = .02) and shorter length of stay (P < .01).

Conclusions:

  • PDW is a valuable indicator for predicting short-term prognosis in pediatric partial-thickness thermal burns.
  • Higher PDW levels are associated with improved wound healing and reduced healthcare burden.
  • PDW can aid clinicians in managing pediatric burn patients more effectively.

Keywords:
burnschildrenplatelet distribution widthprognosiswound healing

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