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Updated: Sep 8, 2025
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Published on: August 8, 2020
The Use of Biologic Wound Agents in Pediatric Reconstructions
Jessica M May1, Monal Depani1, Andrew M Ferry2,3
1Department of Plastic Surgery, University of Texas Southwestern Medical Center, Dallas, Texas.
Insights
Biologic wound agents are increasingly used for pediatric reconstructive surgery. This review details acellular and cellular biologic wound agents for pediatric patients, highlighting their benefits in managing complex defects.
Area of Science:
- Regenerative Medicine
- Pediatric Surgery
- Wound Healing
Background:
- Biologic wound agents, initially for burns, now have expanded indications.
- Literature predominantly covers adult use, with limited data on pediatric applications.
- Pediatric patients benefit significantly due to unique anatomical considerations.
Purpose of the Study:
- To review the application of biologic wound agents in pediatric reconstructive surgery.
- To highlight the advantages of these agents in pediatric defect reconstruction.
- To provide a comprehensive overview of acellular and cellular agents for pediatric use.
Main Methods:
- Literature review focusing on pediatric case studies and clinical trials.
- Analysis of acellular and cellular biologic wound agents.
- Evaluation of outcomes in pediatric patients with complex defects.
Main Results:
- Biologic wound agents offer effective solutions for pediatric reconstructive challenges.
- Reduced skin laxity in children enhances the utility of these agents.
- Successful application in various pediatric defect reconstructions noted.
Conclusions:
- Acellular and cellular biologic wound agents are valuable tools in pediatric wound management.
- Further research is warranted to expand evidence-based guidelines for pediatric use.
- These agents represent a promising approach for improving pediatric reconstructive outcomes.
Abstract:
The indications for using biologic wound agents have expanded greatly since first being employed for acute burn management. The majority of the literature details the use of said agents in the adult population; however, there is little representation regarding their uses for reconstructing defects typically observed in the pediatric population. Ironically, children, and to a lesser extent adolescents, greatly benefit from their use given the reduced skin laxity and amount of surrounding tissue available for locoregional tissue transfer when compared with adults. Herein, we detail the use of acellular and cellular biologic wound agents in the pediatric population.
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