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Related Concept Videos

Polymers02:34

Polymers

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The word polymer is derived from the Greek words “poly” which means “many” and “mer” which means “parts”. Polymers are long chains of molecules composed of repeating units of smaller molecules, known as monomers. They either occur naturally, such as DNA and proteins, or can be constructed synthetically, like plastics. They have varied structural characteristics, such as linear chains, branched chains, or complex networks, that contribute to the...
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Conjugated Proteins02:50

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Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
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Anionic Chain-Growth Polymerization: Overview01:20

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The polymerization process that involves carbanion as an intermediate is called anionic polymerization. It is also a type of addition or chain-growth polymerization. Anionic polymerization gets initiated by a strong nucleophile such as an organolithium or a Grignard reagent. The most commonly used initiator for anionic polymerization is butyl lithium. Monomers involved in anionic polymerization must possess a vinyl group bonded to one or two electron-withdrawing groups. For instance,...
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Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications
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Conjugated polymers for biomedical applications.

Hongrui Lin1,2, Haotian Bai1, Zhiwen Yang1,2

  • 1Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China. wangshu@iccas.ac.cn.

Chemical Communications (Cambridge, England)
|June 16, 2022
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Summary
This summary is machine-generated.

Conjugated polymers (CPs) are versatile organic semiconductors showing promise in biomedical applications. This review highlights their latest advancements in biotherapy, biological regulation, and bioprinting, alongside future challenges.

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Area of Science:

  • Materials Science
  • Biomedical Engineering
  • Organic Electronics

Background:

  • Conjugated polymers (CPs) are organic semiconductors with unique photophysical and photoelectric properties.
  • Their delocalized electronic structures and tunable side chains enable diverse biomedical functionalities.
  • CPs can be synthesized into nanoparticles for controlled size and dispersion.

Purpose of the Study:

  • To review recent developments of conjugated polymers in the biomedical field.
  • To explore applications in biotherapy, biological regulation, biological response, and bioprinting.
  • To discuss current challenges and future outlooks for CPs in biomedicine.

Main Methods:

  • Literature review focusing on recent advancements in conjugated polymer research for biomedical applications.
  • Analysis of CPs' properties, including photophysical characteristics, photoelectric effects, and functionalized side chains.
  • Examination of synthesis methods for nanoparticle preparation and their impact on particle characteristics.

Main Results:

  • CPs demonstrate significant potential in fluorescence imaging, photodynamic therapy, and photothermal therapy.
  • Functionalized side chains enhance water-solubility, biocompatibility, and biological response.
  • Nanoparticle formulations of CPs offer controllable particle size and improved dispersion.

Conclusions:

  • Conjugated polymers are rapidly evolving materials for diverse biomedical applications.
  • Further research is needed to address challenges and fully realize their therapeutic and diagnostic potential.
  • The review provides insights into the future trajectory of CPs in advanced biomedical fields.