Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

311
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
311
Vaccinations01:51

Vaccinations

45.3K
Overview
45.3K
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

914
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
914
Cancer Vaccines01:30

Cancer Vaccines

509
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
509
Humoral Immune Responses01:36

Humoral Immune Responses

75.4K
Overview
75.4K
Development of Immunocompetence01:22

Development of Immunocompetence

444
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
444

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Research progress and challenges of multimodal deep learning models for prognosis of gastric cancer.

Discover oncology·2026
Same author

Metabolic Tagging of Tumour Extracellular Vesicles for Targeted Modulation of Dendritic Cells.

Journal of extracellular vesicles·2026
Same author

Effects of Intensive Prevention of Spillage Measures During Laparoscopic Surgery on Prognosis in Stage IA and Low-Grade Endometrial Cancer: A Retrospective Cohort Study.

Journal of minimally invasive gynecology·2026
Same author

Mapping the global research landscape and hotspots of traditional herbal medicine for inflammatory bowel disease: A bibliometric analysis.

Medicine·2026
Same author

Self-adjuvanting α-helical polypeptide simultaneously delivers neoantigen mRNAs and activates dendritic cells to eradicate tumors.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

In vivo metabolic tagging and targeting of circulating red blood cells.

Nature communications·2026

Related Experiment Video

Updated: Sep 7, 2025

Synthesis and Characterization of mRNA-Loaded PolyBeta Aminoesters Nanoparticles for Vaccination Purposes
08:27

Synthesis and Characterization of mRNA-Loaded PolyBeta Aminoesters Nanoparticles for Vaccination Purposes

Published on: August 13, 2021

4.7K

Materials-based vaccines for infectious diseases.

Yang Bo1, Hua Wang1,2,3,4,5,6,7

  • 1Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.

Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
|June 16, 2022
PubMed
Summary

Biomaterials-based vaccines offer a promising approach to combat infectious diseases by enhancing immune responses. These advanced vaccines overcome limitations of conventional methods, improving protection against challenging pathogens.

Keywords:
adjuvantantigenimmune responseinfectious diseasepathogenvaccine

More Related Videos

Enrichment of Native and Recombinant Extracellular Vesicles of Mycobacteria
06:38

Enrichment of Native and Recombinant Extracellular Vesicles of Mycobacteria

Published on: December 8, 2023

1.1K
Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen
07:44

Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen

Published on: May 12, 2023

1.3K

Related Experiment Videos

Last Updated: Sep 7, 2025

Synthesis and Characterization of mRNA-Loaded PolyBeta Aminoesters Nanoparticles for Vaccination Purposes
08:27

Synthesis and Characterization of mRNA-Loaded PolyBeta Aminoesters Nanoparticles for Vaccination Purposes

Published on: August 13, 2021

4.7K
Enrichment of Native and Recombinant Extracellular Vesicles of Mycobacteria
06:38

Enrichment of Native and Recombinant Extracellular Vesicles of Mycobacteria

Published on: December 8, 2023

1.1K
Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen
07:44

Fabrication of Pulsatile Polymeric Microparticles Encapsulating Rabies Antigen

Published on: May 12, 2023

1.3K

Area of Science:

  • Nanomedicine
  • Infectious Disease Therapeutics
  • Vaccinology

Background:

  • Infectious diseases remain a leading cause of global mortality, with pathogens like HIV, malaria, influenza, and SARS-CoV-2 posing significant threats.
  • Conventional vaccines often fall short in controlling highly virulent or deadly pathogens due to limitations in antigen presentation and adjuvant synergy.
  • Understanding disease mechanisms is crucial but often lags, hindering the development of effective therapeutics.

Purpose of the Study:

  • To review different types of materials-based vaccines for eliciting cellular and humoral immune responses against pathogens.
  • To discuss design criteria for enhancing the efficacy of materials-based vaccines.
  • To highlight the potential of nanomedicine in infectious disease control.

Main Methods:

  • Review of current literature on materials-based vaccine strategies.
  • Analysis of biomaterial properties relevant to vaccine development.
  • Discussion of in situ immune cell manipulation and delivery advantages.

Main Results:

  • Materials-based vaccines demonstrate potential to synergize antigen and adjuvant functions.
  • Biomaterials can address delivery challenges and modulate immune cell activity.
  • These vaccines show promise for generating robust cellular and humoral immunity.

Conclusions:

  • Biomaterials-based vaccines represent a significant advancement over conventional approaches for infectious diseases.
  • Strategic design of materials is key to maximizing vaccine efficacy and immune response.
  • Nanomedicine offers innovative solutions for developing next-generation vaccines against global health threats.